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Int J Clin Exp Pathol 2013;6(7):1223-1229

Review Article
The role of TP53 network in the pathogenesis of chronic lymphocytic leukemia

Cheng Wang, Xin Wang

Department of Hematology, Provincial Hospital Affiliated to Shandong University, No. 324 Jingwu Road, Jinan, Shandong 250021, P. R. Chi-na;
Department of Hematology, Provincial Hospital affiliated to Shandong University, Jinan, Shandong 250012, P. R. China; Department of
Diagnostics, Shandong University School of Medicine, Jinan, Shandong 250012, P. R. China

Received April 26, 2013; Accepted May 11, 2013; Epub June 15, 2013; Published July 1, 2013

Abstract: TP53 is one of the most important prognostic factors in chronic lymphocytic leukemia (CLL). Modulation of microRNAs by TP53 in
CLL pathogenesis has been a hotspot. Besides, it has an intimate association with other cytogenetics and plays an important part in drug
resistance of CLL. All above indicate an embedded TP53-centered network in CLL pathogenesis and prognosis. In this review, we focus on the
TP53-centered network and its roles in the pathogenesis of CLL. (IJCEP1304037).

Keywords: TP53 network, microRNAs, chronic lymphocytic leukemia, pathogenesis

Address correspondence to: Dr. Xin Wang, Department of Hematology, Provincial Hospital affiliated to Shandong University, No. 324, Jingwu
Road, Jinan, Shandong, 250021, China. Phone: 86-531-85186358 (B); 86-13156012606 (M); Fax: 0086-0531-87068707 (B); E-mail:
xin-wang55@yahoo.com.cn