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Int J Clin Exp Pathol 2013;6(8):1467-1480

Original Article
Histopathological and functional effects of antimony on the renal cortex of growing
albino rat

Ahmed H Rashedy, Adnan A Solimany, Ayman K Ismail, Mohamed H Wahdan, Khalid A Saban

Department of Pathology, College of Medicine, Taif University, KSA; Department of Pediatric, College of Medicine, Taif University, KSA;
Departments of Forensic Medicine and Toxicology, College of Medicine, Taif University, KSA; Departments of Forensic Medicine and Toxicology,
Suez Canal University, Egypt; Department of Anatomy, College of Medicine, Taif University, KSA; Department of Nuclear Medicine, College of
Medicine, Taif University, KSA

Received April 28, 2013; Accepted July 9, 2013; Epub July 15, 2013; Published August 1, 2013

Abstract: Contamination of the environment with antimony compounds may affect human health through the persistent exposure to small
doses over a long period. Sixty growing male albino rats, weighing 43-57 grams, utilized in this study. The animals were divided into 3 groups;
each of 20 rats: animals of group I served as control, animals of group II received 6 mg/kg body weight antimony trisulfide daily for 8 weeks with
drinking water, and those of group III received the same dose by the same route for 12 weeks. The Malpighian renal corpuscles showed
distortion, destruction and congestion of glomerular tuft, vacuoles in the glomeruli, peritubular haemorrhage, obliteration of Bowman’s space,
and thickening with irregularity of Bowman’s membrane. The proximal convoluted tubules demonstrated patchy loss of their brush border,
thickening of the basement membrane with loss of its basal infoldings, disarrangement of the mitochondria, pleomorphic vacuoles in the
cytoplasm, apical destruction of the cells, apical migration of the nuclei, and absence of microvilli. On the other hand, peri-tubular hemorrhage,
apical vacuolation, small atrophic nuclei, swelling of mitochondria, obliteration of the lumina, destruction of cells, and presence of tissue debris
in the lumina, were observed in the distal convoluted tubules. The present work demonstrated the hazardous effect of antimony on the renal
function as evidenced by the significant increase of the level of blood urea, serum creatinine, and serum sodium and potassium. In conclusion,
this study proposed that continuous oral administration of antimony for 8 and 12 weeks has hazardous toxic effect on the structure and function
of the kidney in growing albino rat. Based on the results of the present study, it is recommended to avoid the use of any drinking water
contaminated with antimony compounds and forbidden its use in infants and children foods. (IJCEP1304038).

Keywords: Antimony, histopathology, blood chemistry, renal cortex, growing albino rat

Address correspondence to: Dr. Ayman K Ismail, Department of Clinical Pharmacology, Forensic Medicine and Toxicology section, College of
Medicine, Taif University, Taif, Saudi Arabia. Phone: 00966 02 7272966, ext. 1035; Cellular: 00966 0530049672; E-mail: aykam4@yahoo.com;
aymanka@tu.edu.sa