IJCEP Copyright © 2007-All rights reserved.
Int J Clin Exp Pathol 2013;6(7):1416-1421

Case Report
Metastasis germinomas of the external acoustic meatus: in a 19-year-boy: a case report

Rong Zhao, Jiang Wang, Ya Ba, Qiong Zhang

Department of Nuclear Medicine, Urumqi General Hospital of Lanzhou Military Region, Urumqi, Xinjiang, 830002, China; Department of
General Surgery, Urumqi General Hospital of Lanzhou Military Region, Urumqi, Xinjiang, 830002, China; Department of Nuclear Medicine, The
First Affiliated Hospital of Xinjiang Medical College, Urumqi, Xinjiang, 830002, China; Medical Department, Urumqi General Hospital of Lanzhou
Military Region, Urumqi, Xinjiang, 830002, China. Equal contributors.

Received May 7, 2013; Accepted May 22, 2013; Epub June 15, 2013; Published July 1, 2013

Abstract: Background: The external acoustic meatus metastasis of germinomas is a rare event. Case presentation: we describe a 19-year-old
boy with stuffiness and earplug of the left ear but no other symptoms. The whole body F-18 FDG PET/CT and the brain MRI are performed and
demonstrated a germinoma in the pineal gland and vermis cerebellum region and in the right of thalamus. Photomicrograph showing marked
infiltration of lymphoplasma cells and macrophages including giant cells. Immunohistochemical analysis results demonstrated the tumor cells
are strongly positive for CD117 and PLAP. The final diagnosis was germinoma and all adjuvant therapy was achieved. Conclusion: Although
the external acoustic meatus metastasis of germinomas is rare, the diagnosis should be taken into serious consideration in order to improve.
In addition, F-18 FDG PET/CT was very useful in diagnosis primary disease and excluding distant metastases. To our knowledge, this is the
first published report of this type of case. (IJCEP1305006).

Keywords: Germinomas, external acoustic meatus, immunohischemistry, F-18 FDG PET/CT

Address correspondence to: Dr. Qiong Zhang, Urumqi General Hospital of Lanzhou Military Region, Urumqi, Xinjiang, 830002, China. E-mail:
zhangqiong_z@yahoo.com.cn