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Int J Clin Exp Pathol 2013;6(7):1362-1366

Original Article
Aberrant staining patterns of E-cadherin and β-catenin: a potential diagnostic value for
distinguishing vulvar intraepithelial neoplasia from non-neoplastic vulvar lesions

Bo Li, Qingfu Zhang, Ling Ouyang, Lin Jia, Xue Han, Yang Zhou, Xin Tong, Zixuan Song, Shulang Zhang, Xueshan Qiu

Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, 110004, China; Department of
Pathology, the First Affiliated Hospital of China Medical University, Shenyang 110001, China

Received May 14, 2013; Accepted May 29, 2013; Epub June 15, 2013; Published July 1, 2013

Abstract: Histologically, vulvar intraepithelial neoplasm (VIN) is a proliferative disorder of the female vulva. No single clinical characteristic or
pathognomonic feature facilitates the diagnosis of VIN, and the agreement between different pathologists on the diagnoses varies significantly.
In this study, we evaluate the immunohistochemical expression patterns of E-cadherin and β-catenin in 22 patients with VIN and 10 patients
with non-neoplastic vulvar lesions. our results showed that membranous staining for E-cadherin and β-catenin was observed in squamous
epithelial cells of all control non-neoplastic vulvar samples. Abnormal E-cadherin (17/19, 89.5%) and β-catenin (15/19, 78.9%) staining
occurred more frequently in usual-type VIN than in non-neoplastic vulvar lesions (P=0.000 and P=0.000, respectively). However, in differentiated
VIN, only 1 patient showed abnormal E-cadherin and β-catenin immunohistochemical expressions, which did not differ significantly. The
abnormal expression of E-cadherin and β-catenin proteins might be useful in distinguishing VIN from non-neoplastic vulvar squamous
epithelium lesions in problematic cases. (IJCEP1305021).

Keywords: β-catenin, E-cadherin, vulvar intraepithelial neoplasia, immunohistochemistry

Address correspondence to: Dr. Ling Ouyang, Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University,
Shenyang 110004, China. E-mail: ouyangl1964@126.com