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Int J Clin Exp Pathol 2013;6(7):1432-1436

Case Report
A case of myxoid liposarcoma of the breast

Tsuyoshi Saito, Misa Ryu, Yuki Fukumura, Miki Asahina, Atsushi Arakawa, Katsuya Nakai, Hiroyoshi Miura, Mitsue Saito, Takashi Yao

Department of Human Pathology, Juntendo University School of Medicine, Tokyo, Japan; Department of Breast Oncology, Juntendo University
School of Medicine, Tokyo, Japan

Received May 20, 2013; Accepted June 4, 2013; Epub June 15, 2013; Published July 1, 2013

Abstract: A 70-year-old woman visited a local hospital complaining of a nodulein the right breast, present since 1 month. She was referred to
our hospital for further evaluation. Following mammotome (MMT) biopsy, the nodule was diagnosed as myxoid/round cell liposarcoma. She
underwent total mastectomy of the right breast. Histological analysis indicated that the tumor was almost entirely composed of proliferating
small round mesenchymal cells in amyxoid matrix background with capillary-like vessels with partial necrosis (<10%). Immunohistochemically,
p53 positive cells were seen focally (<1%) only, and the Ki-67 labeling index was approximately 20%. Sincethe surgical margin was
histologically positive despite pathologic findings of high-grade malignancy, adjuvant treatment involving local radiation therapy (60Gy) was
administered. The patient was free from any symptoms of local recurrence and metastases 1 year and 8 months after surgery.

Keywords: Myxoid liposarcoma, round cell component, breast

Address correspondence to: Dr. Tsuyoshi Saito, Department of Human Pathology, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo
113-8421, Japan. Tel: +813-3813-3111; E-mail: tysaitou@juntendo.ac.jp