|IJCEP Copyright © 2007-All rights reserved.
Int J Clin Exp Pathol 2013;6(8):1558-1566
Expression of Snail transcription factor in prostatic adenocarcinoma in Egypt: correlation
with Maspin protein expression and clinicopathologic variables
Ashraf Ishak Fawzy, Mariana Fathy Gayyed, Gamal Abd Elhamid Elsaghir, Mohamed Salah Elbadry
Department of Pathology, Faculty of Medicine, Minia University, El-Minia, Egypt; Department of Urology, South Valley University, Qena, Egypt;
Department of Urology, Minia University Hospital, Minia University, El-Minia, Egypt. Equally contributors.
Received May 23, 2013; Accepted June 7, 2013; Epub July 15, 2013; Published August 1, 2013
Abstract: Background: Snail transcription factor and Maspin tumor suppressor serpin are involved in the regulation of progression, invasion
and metastasis of many human malignancies. However, there is very limited data in the literature about their role in prostatic adenocarcinoma.
The present study was designed to investigate Snail and Maspin expression, their interrelationship and their relationship to different
clinicopathologic variables in clinically detectable prostatic adenocarcinoma. Material and methods: Tissue sections from 110 resected
prostatic lesions distributed as 80 cases of prostatic adenocarcinoma and 30 cases of benign prostatic hyperplasia (BPH) were evaluated for
Snail and Maspin proteins expression by immunohistochemistry. Results: Snail protein expression was detected in 53.8% of prostatic
adenocarcinomas versus none of BPH cases (p = < 0.001). A significant positive correlation of Snail expression to cancer grade (p = 0.015),
lymph node metastasis (p = 0.026) and pTNM stage (p = 0.036). Maspin expression was detected in 36.6% of prostatic adenocarcinomas
versus 93.3% of BPH cases (p = < 0.001). A significant negative correlation of Maspin expression to cancer grade (p = 0.007) and
lymphovascular invasion (p = 0.017). Also detected was a significant negative relationship between Snail and Maspin expression in cancer
cases under investigation (p = 0.002). Conclusion: Snail immunohistochemical expression can be promising as a potential prognostic
biomarker in prostatic adenocarcinoma since it was significantly associated with clinicopathologic variables of progressive disease. A potential
role for Snail in regulating Maspin expression is suggested based on the finding of negative association between Snail and Maspin expression
in prostatic adenocarcinoma. (IJCEP1305031).
Keywords: Benign prostatic hyperplasia, immunohistochemistry, Maspin, prostatic adenocarcinoma, Snail, clinicopathologic variables
Address correspondence to: Dr. Mariana Fathy Gayyed, Department of Pathology, Faculty of Medicine, Minia University, Minia, Egypt, 61111.
Phone: (002) 01001143941; E-mail: email@example.com; firstname.lastname@example.org