IJCEP Copyright © 2007-All rights reserved.
Int J Clin Exp Pathol 2013;6(8):1617-1623

Original Article
Association of the brain-derived neurotrophic factor gene G196A rs6265 polymorphisms
and the cognitive function and clinical symptoms of schizophrenia

Jinguo Zhai, Qing Yu, Min Chen, Yan Gao, Qiumei Zhang, Jun Li, Keqin Wang , Feng Ji, Zhonghua Su, Wu Li, Xuemei Li, Juyao Qiao

School of Mental Health, Jining Medical University, #16 Hehua Road, Jining 272067, Shandong Province, PR China; Department of Psychiatry,
the Second Affiliated Hospital, Jining Medical University, #1 Jidai Road, Jining 272051, Shandong Province, PR China; State Key Laboratory of
Cognitive Neuroscience and Learning, Beijing Normal University, #19 Xinjiekouwai Street, Haidian District, Beijing 100875, PR China. Equal
contributors.

Received June 5, 2013; Accepted July 3, 2013; Epub July 15, 2013; Published August 1, 2013

Abstract: This study aimed to explore the association between BDNF G196A gene rs6265 polymorphisms and the cognitive function and
clinical symptoms of schizophrenia. Methods: BDNF G196A rs6265 genotype and allele frequency were measured using Polymerase Chain
Reaction (PCR) methods in 224 drug-free patients with schizophrenia and 220 controls. Psychotic symptoms were assessed using the
Positive and Negative Syndrome Scale (PANSS), and cognitive functioning was assessed using the Wisconsin Card Sorting Test (WCST) and
the Trail Making Test (TMT). In the patient group, differences in severity of symptoms across the three genotypes (i.e., G/G, G/A and A/A) of
G196A were assessed using one-way analysis of variance. Results G/A genotype had higher frequencies than GG or AA genotype in both
patients and controls. There was no significant difference in G/G, G/A, A/A genotype frequency between patients and controls (P > 0.05). The
allele G had higher frequencies than allele A in both patients and controls. There was no significant difference in G or A allele frequency
between patients and controls (P > 0.05). There was significant difference in A/A genotype frequency between positive group patients and
negative group patients. There was no significant difference in cognitive performance between patients with G/G, G/A and A/A genotype (all P >
0.05). Conclusion BDNF G196A gene rs6265 polymorphism is not associated with the cognitive function but with the clinical symptoms of
schizophrenia. (IJCEP1306005).

Keywords: Brain-derived neurotrophic factor, G196A gene, cognitive function, molecular psychiatry, schizophrenia

Address correspondence to: Dr. Jun Li, State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, #19
Xinjiekouwai Street, Haidian District, Beijing 100875, PR China. Phone: +86-13691008200; Fax: +86-537-3165666; E-mail:
lijunlijun1@126.com; lijundp@bnu.edu.cn