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Int J Clin Exp Pathol 2013;6(8):1665-1670

Case Report
Urethral adenocarcinoma associated with intestinal-type metaplasia, case report and
literature review

Christopher S Hale, Hongying Huang, Jonathan Melamed, Ruliang Xu, Larry Roberts, Rosemary Wieczorek, Zhiheng Pei, Peng Lee

Department of Pathology, New York Harbor Healthcare System, New York University School of Medicine, New York, NY, USA; Sound Shore
Medical Center, New Rochelle, NY, USA

Received June 6, 2013; Accepted July 8, 2013; Epub July 15, 2013; Published August 1, 2013

Abstract: The presence of glandular epithelium in urinary tract biopsies poses a diagnostic challenge. Intestinal metaplasia of the urethra may
be seen in many congenital, iatrogenic, and reactive conditions, as well as in association with malignant conditions such as urethral
adenocarcinoma. We present a case of a 61 year-old woman presenting with microscopic hematuria. Successive biopsies showed glandular
epithelium with focal atypia in close association with inflammation, but no overt malignancy. Only on surgical resection was the associated
high grade adenocarcinoma revealed. When intestinal-type mucosa is present within a urinary tract biopsy, associated malignancy may be
present only focally. Thorough sampling and consideration of the differential diagnosis is imperative. (IJCEP1306007).

Keywords: Urethral adenocarcinoma, intestinal metaplasia

Address correspondence to: Dr. Peng Lee, Departments of Pathology and Urology, New York Harbor Healthcare System, New York University
School of Medicine, 423 E. 23rd Street, Room 6139N, New York, NY, USA. E-mail: peng.lee@nyumc.org