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Int J Clin Exp Pathol 2013;6(10):2247-2250

Case Report
Paraganglioma of the vulva: a case report and review of the literature

Yong-Qiao Liu, Jun-Qiu Yue

Department of Pathology, People’s Hospital of Yingcheng, Yingcheng, Hubei, China; Department of Pathology, Hubei Cancer Hospital, Wuhan,
Hubei, China

Received July 6, 2013; Accepted August 19, 2013; Epub September 15, 2013; Published October 1, 2013

Abstract: Paraganglioma is a neuroendocrine neoplasm, which is extremely rare in the vulva and only one case has been reported. Here we
present a case of vulvar paraganglioma in a 48-year-old woman and a literature review. The patient found a lump located in the genitals below
the symphysis pubis 3 months before presentation when she complained that the lump was increasing in size. A 3.2 cm x 2.3 cm x 1.5 cm
nodule was excised from subcutaneous soft tissue in the vulva. Microscopy showed a diversity of cell morphologies and structures in the rich
vascular network of the tumor separated the chief cells into round cell nests (Zellballen pattern). Some areas of the tumor presented epithelioid
and spindle-shaped cells with increased cell density and indistinct structural characteristics. Hyaline degeneration of collagen fibers or mucoid
degeneration was found in tumor interstitium. Immunohistochemical staining showed diffused expression of synaptophysin in the chief cells,
focal expression of S-100 protein in the sustentacular cells and high expression of CD34 in the vascular components. Based on morphological
and immunohistochemical results, a rare paraganglioma of the vulva was diagnosed. (IJCEP1307013).

Keywords: Paraganglioma, vulva, Syn, S-100, immunohistochemistry

Address correspondence to: Dr. Jun-Qiu Yue, Department of Pathology, Hubei Cancer Hospital, 116 Zhuodaoquan South Road, Wuhan
430079, China. Tel: 86-15071118102; Fax: 86-027-87670469; E-mail: yuejunqiu@gmail.com (JQY); Yong-Qiao Liu, Department of Pathology,
People’s Hospital of Yingcheng, Yingcheng, Hubei, China. E-mail: liuyongqiao98@163.com (YQL)