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Int J Clin Exp Pathol 2013;6(11):2280-2291

Original Article
The effect of porcine ADM to improve the burn wound healing

Xiaodong Chen, Yan Shi, Bin Shu, Xiaoxia Xie, Ronghua Yang, Lijun Zhang, Shubin Ruan, Yan Lin, Zepeng Lin, Rui Shen, Fenggang Zhang,
Xiangsheng Feng, Julin Xie

Department of Burn Surgery, Fo Shan Hospital of Sun Yat-Sen University, Foshan, Guangdong, China; Department of Burn Surgery, First
Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China. The first two authors contributed equally to this article and should
be considered as cofirst authors.

Received July 10, 2013; Accepted August 30, 2013; Epub October 15, 2013; Published November 1, 2013

Abstract: To study the effect of porcine acellular dermal matrix (ADM) on the burn wound healing. Seventy healthy Wistar rats were inflicted with
2 cm second degree burn and divided into 2 groups; one group was treated with porcine ADM and the other with Povidone Iodine Cream.
Biopsies were taken on day 1, 3, 5, 7, 10, 14, 21 for histopathological and biochemical analysis to test PCNA, K19, Integrin-β1, PDGF, EGF and
FGF. The results revealed relatively better and faster regeneration after treatment of porcine ADM, along with greatly increased synthesis in
collagen in the experimental group. PCNA, K19, Integrin-β1 had an increase and then tapered down, and were stronger in the experimental
group than in the contrast group during 21 days after burns. PDGF, EGF and FGF levels increased on day 3, peaked on day 5 and then started
to decrease, while significantly enhanced expression of relevant growth factors were observed in the experimental group. Porcine ADM
stimulate collagen synthesis, stem cells proliferation and differentiation, and the expression of relevant growth factors and ultimately improve
the burn wound healing. (IJCEP1307019).

Keywords: Porcine ADM, deep partial thickness burn wounds, PCNA, K19, Integrin-β1, PDGF

Address correspondence to: Julin Xie, Department of Burn Surgery, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong
510080, China. Tel: 0086-013802807158; Fax: 0086-20-87335577; E-mail: xiejl90@sina.com