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Int J Clin Exp Pathol 2013;6(9):1894-1902

Original Article
The association of Pro12Ala polymorphism in the peroxisome proliferator-activated
receptor-gamma2 gene with the metabolic characteristics in Chinese women with
polycystic ovary syndrome

Jiejin Yang, Hao Gong, Wei Liu, Tao Tao

Department of Internal Medicine Renji Hospital, Division of Endocrinology and Metabolism, Shanghai Jiaotong University School of Medicine,
1630 Dongfang Road, Pudong, Shanghai, 200127, China; Department of Internal Medicine, Division of Emergency, Renji Hospital, Shanghai
Jiaotong University School of Medicine, 1630 Dongfang Road, Pudong, Shanghai, 200127, China. Equal contributors.

Received July 12, 2013; Accepted August 3, 2013; Epub August 15, 2013; Published September 1, 2013

Abstract: Background: The Pro12Ala polymorphism in the peroxisome Proliferator-activated receptor-gamma2 PPARγ2) gene that account for
metabolic dysfunction in women with polycystic ovary syndrome (PCOS) remain elusive. Aim: To explore the association between PPARγ2 gene
pro12ala polymorphism and the metabolic characteristics in Chinese women with PCOS. Methods: PPARγ2 gene Pro12Ala polymorphism was
assayed by PCR/RFLP methods in 120 Chinese women with PCOS and 118 normal subjects. All subjects were examined by anthropometry,
lipid profile, sex hormone, oral glucose tolerance tests and insulin tolerance tests. Results: In PCOS patients, women with the non-Pro/Pro
genotypes of the PPARγ2 gene Pro12Ala polymorphism showed statistically significantly higher fasting triglycerides (TG) levels and WHR value
than those with the Pro/Pro genotype (P=.006 for both). There was no significant difference with PPARγ2 Pro12Ala polymorphism distributions
between Chinese Han women with PCOS and controls. Conclusion: PPARγ2 gene Pro12Ala polymorphism was not supposed to be
susceptible genes in PCOS. However, in PCOS patients, the PPAR-gamma Pro12Ala polymorphism may modulate the concentrations of
serum fasting TG levels and fat-deposition in abdomen, respectively. (IJCEP1307021).

Keywords: Polycystic ovary syndrome, peroxisome proliferator-activated receptor-gamma2, polymorphism, central obesity, hypertriglyceridemia

Address correspondence to: Dr. Wei Liu and Dr. Tao Tao, Department of Internal Medicine Renji Hospital, Division of Endocrinology and
Metabolism, Shanghai Jiaotong University School of Medicine, 1630 Dongfang Road, Pudong, Shanghai, 200127, China. Tel: 86-21-68383083;
Fax: 86-21-68383523; E-mail: sue_liuwei@163.com (Wei Liu); taotaozhen@hotmail.com (Tao Tao)