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Int J Clin Exp Pathol 2013;6(10):2257-2262

Case Report
Synovial sarcoma of the neck masquerading as a malignant second branchial cleft cyst

Yao-Shu Teng, Zhi-Hong Lin, Yong Li, Xiao-Lin Cao, Feng-Chun Lin, Jing-Jing Xiang

Departments of Otorhinolaryngology, Pathology, Hangzhou First People’s Hospital, Hangzhou, 310006, P.R. China; Departments of
Otorhinolaryngology, Pathology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310009, P.R. China

Received July 31, 2013; Accepted August 15, 2013; Epub September 15, 2013; Published October 1, 2013

Abstract: Synovial sarcoma is an uncommon, aggressive malignant tumor of the soft tissues primarily involving the extremities of young
adults. Head and neck synovial sarcoma is rare, and its diagnosis and therapy are still challenging. We report a case of a young patient with
synovial sarcoma, clinically masquerading as cystic mass of the neck and malignant second branchial cleft cyst. The pathological diagnosis of
the sarcoma was confirmed by a multimodality diagnostic protocol, including histological, immunohistochemical and molecular genetic
analysis. The patient underwent complete surgical excision followed by postoperative radiotherapy and recovered well. (IJCEP1307052).

Keywords: Synovial sarcoma, head and neck, branchial cleft cyst, molecular genetic testing

Address correspondence to: Dr. Zhi-Hong Lin, Department of Otorhinolaryngology, Second Affiliated Hospital, School of Medicine, Zhejiang
University, Hangzhou 310009, P.R. China. Tel: 0086-13516809921; E-mail: sun6406@126.com