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Int J Clin Exp Pathol 2013;6(10):2208-2215

Case Report
Angiofibroma of soft tissue: clinicopathologic study of 2 cases of a recently
characterized benign soft tissue tumor

Ming Zhao, Ke Sun, Changshui Li, Jiangjiang Zheng, Jingjing Yu, Jie Jin, Wenping Xia

Department of Pathology, Department of Radiology, Ningbo Yinzhou Second Hospital, Ningbo, Zhejiang 315100, China; Department of
Pathology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, China

Received August 4, 2013; Accepted August 27, 2013; Epub September 15, 2013; Published October 1, 2013

Abstract: Angiofibroma of soft tissue is a very recently characterized, histologically distinctive benign mesenchymal neoplasm of unknown
cellular origin composed of 2 principal components, the spindle cell component and very prominent stromal vasculatures. It usually occurs in
middle-aged adults, with a female predominance. Herein, we describe the clinical and pathologic details of 2 other examples of this benign
tumor. Both patients were middle-aged male and presented with a slow-growing, painless mass located in the deep-seated soft tissue of
thigh and left posterior neck region, respectively. Grossly, both tumors were well-demarcated, partial encapsulated of a grayish-white color with
firm consistence. Histologically, one case showed morphology otherwise identical to those have been described before, whereas the other
case showed in areas being more cellular than most examples of this subtype tumor had, with the lesional cells frequently exhibiting short
fascicular, vaguely storiform and occasionally swirling arrangements, which posed a challenging differential diagnosis. Immunostains
performed on both tumors did not confirm any specific cell differentiation with lesional cells only reactive for vimentin and focally desmin and
negative for all the other markers tested. This report serves to broaden the morphologic spectrum of angiofibroma of soft tumor. Awareness of
this tumor is important to prevent misdiagnosis as other more aggressive soft tissue tumor. (IJCEP1308009).

Keywords: Soft tissue tumor, benign, angiofibroma, fibrovasular tumor, differential diagnosis

Address correspondence to: Dr. Ming Zhao, Department of Pathology, Ningbo Yinzhou Second Hospital, No.1 North Qianhe Road, Yinzhou
District, Ningbo, Zhejiang 315100, China. Tel: +86-574-83039018; Fax: +86-574-83038515; E-mail: zhaomingpathol@163.com