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Int J Clin Exp Pathol 2013;6(10):1964-1971

Review Article
Ovarian stimulation for in vitro fertilization alters the protein profile expression in
endometrial secretion

Ming-Qing Li, Li-Ping Jin

Laboratory for Reproductive Immunology, Hospital and Institute of Obstetrics and Gynecology, Fudan University Shanghai Medical College,
Shanghai 200011, People’s Republic of China; Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai
200011, People’s Republic of China

Received August 12, 2013; Accepted August 29, 2013; Epub September 15, 2013; Published October 1, 2013

Abstract: Failure of the embryo to implant now constitutes the major limiting step in IVF treatment. Successful implantation requires a vital
embryo and an effective molecular dialogue with a ‘receptive’ endometrium. However, what precisely constitutes a receptive human
endometrium remains poorly defined. Several observations have indicated that ovarian stimulation for IVF may impair endometrial receptivity.
The histological approach to monitor endometrial maturation requires an invasive biopsy that excludes its use during the luteal phase of cycles
in which implantation is the end-point objective as in IVF. In recent years, several studies have been reported that the removal of endometrial
secretions immediately prior to embryo transfer provides sufficient material for analysis of markers of receptivity without disrupting embryo
implantation. Therefore, analysis of protein patterns in endometrial secretion fluid may offer a relatively non-invasive means of assessing
endometrial receptivity during fertility treatment cycles. Several studies have shown that protein profile expression in endometrial secretions
undergo cyclical changes, and demonstrated significant differences between the natural cycle and stimulated cycle. These findings suggest
that endometrial secretion analysis provide a novel means of investigating the effect of ovarian stimulation on the intrauterine environment at
the time of embryo transfer, which may help to develop less disruptive ovarian stimulation protocols for IVF in the future. (IJCEP1308023).

Keywords: Ovarian stimulation, endometrial secretion, endometrial receptivity, cytokine, in vitro fertilization

Address correspondence to: Dr. Li-Ping Jin, Laboratory for Reproductive Immunology, Hospital and Institute of Obstetrics and Gynecology,
Fudan University Shanghai Medical College, Shanghai 200011, China. E-mail: zjplp2004@yahoo.com.cn