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Int J Clin Exp Pathol 2013;6(11):2609-2614

Case Report
Histiocytoid breast carcinoma: a case report showing immunohistochemical profiles

Peifeng Li, Jinfeng Zheng, Tingguo Zhang, Ruixue Cao, Xin Chen, Ming Geng

Department of Pathology, General Hospital of Jinan Military Command, Jinan, Shandong Province 250031, China; Department of Graduate
Division, Weifang Medical University, Weifang, China. Equal contributors.

Received August 13, 2013; Accepted August 28, 2013; Epub October 15, 2013; Published November 1, 2013

Abstract: Histiocytoid breast carcinoma (HBC) is a rare type of breast cancer with a controversial histogenesis. Here we describe a case report
of a 65-year old woman with HBC. The patient presented with two masses in the right breast. Histopathologically, the tumors consisted of a
diffuse infiltration of large tumor cells and histological components of carcinoma in situ and atypical lobular hyperplasia were also observed.
The infiltration pattern was similar to that of invasive lobular carcinoma with targetoid and Indian file arrangements. The invasive histiocytoid
cells had finely granular, eosinophilic to vesicular cytoplasm and nuclei with a bland uniform appearance, a single small eosinophilic
nucleolus and finely granular chromatin. We compared the immunohistochemical profiles of 17 breast cancer markers between invasive
carcinoma, carcinoma in situ, atypical lobular hyperplasia and normal breast epithelium. Although they all shared the same reactivity for many
of the proteins, they exhibited differences in GCDFP-15, E-cadherin, P120, CEA, HER-2, ER and PR expression, and these are discussed. This
is the first case study of two HBC masses occurring in one breast simultaneously. By analyzing and comparing their morphologic
characteristics and spectrum of immunohistochemical expression, our study supports the view that HBC is a variant of lobular carcinoma and
our findings may assist in future diagnoses of HBC. (IJCEP1308031).

Keywords: Histiocytoid, breast cancer, invasive lobular carcinoma, carcinoma in situ, atypical lobular hyperplasia

Address correspondence to: Peifeng Li and Ming Geng, Department of Pathology, General Hospital of Jinan Military Command, Jinan,
Shandong Province 250031, China. E-mail: lipeifeng00@hotmail.com (Peifeng Li); gm2227@sina.com (Ming Geng)