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Int J Clin Exp Pathol 2013;6(10):2224-2229

Case Report
Biclonal light chain gammopathy with aberrant CD33 expression in secondary plasma
cell leukemia

Michael Gentry, Mark Pettenati, Changlee S Pang

Department of Pathology, Wake Forest University Baptist Medical Center, Medical Center Boulevard, Winston Salem, NC 27157, USA

Received August 13, 2013; Accepted August 28, 2013; Epub September 15, 2013; Published October 1, 2013

Abstract: Plasma cell leukemia is a rare neoplastic proliferation of circulating plasma cells. Clonal proliferations of plasma cells, such as in
plasma cell leukemia or plasma cell myeloma, are typically characterized by production of a monoclonal heavy and/or light chain
immunoglobulin. We present a case of a secondary plasma cell leukemia arising from plasma cell myeloma with dual expression of lambda
and kappa light chains along with aberrant expression of CD33, CD20, and dim CD56. This case emphasizes the importance of recognizing
aberrant immunophenotypes in plasma cell leukemias and represents the first reported case of biclonal light chain expression in a secondary
plasma cell leukemia. (IJCEP1308032).

Keywords: Plasma cell leukemia, biclonal gammopathy, aberrant immunophenotype

Address correspondence to: Dr. Changlee S Pang, Department of Pathology, Wake Forest University Baptist Medical Center, Medical Center
Boulevard, Winston Salem, NC 27157, USA. Tel: 336-716-2650; Fax: 336-716-7595; E-mail: cpang@wakehealth.edu