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Int J Clin Exp Pathol 2013;6(10):2199-2207

Original Article
Maternal and neonatal outcomes in dichorionic twin pregnancies following IVF
treatment: a hospital-based comparative study

Cuifang Fan, Yanmei Sun, Jing Yang, Jinping Ye, Suqing Wang

Department of Obstetrics and Gynecology, Department of Reproductive Medicine Center, Department of Neonatology, Renmin Hospital, Wuhan
University, Hubei, China; Department of Nutrition and Food Hygiene, School of Public Health, Wuhan University, Hubei, China

Received August 15, 2013; Accepted August 30, 2013; Epub September 15, 2013; Published October 1, 2013

Abstract: Aim: To compare maternal, and neonatal outcomes in IVF/ICSI and spontaneously conceived dichorionic twin pregnancy. Method: We
collected data regarding dichorionic twin pregnancies following in vitro fertilization/ intracytoplasmic sperm injection (IVF/ICSI, n=162) with the
transfer of fresh embryos as well as data regarding spontaneously conceived pregnancies (n=213) delivered after 28 weeks of gestation at the
Department of Obstetrics and Gynecology, Renmin Hospital in Wuhan in the years of 2010-2013. We then compared maternal and neonatal
outcomes between IVF/ICSI and spontaneous dichorionic twin pregnancies, with a subgroup analysis separating traditional IVF from ICSI
pregnancies. Odds ratios (OR) for associations between IVF/ICSI and pregnancy outcomes were adjusted for maternal factors. Results: The
mean maternal age and the percentage of primiparous women were significantly higher in the IVF/ICSI group. Multivariate analysis revealed
that maternal outcomes were comparable in both groups with/without adjustment for maternal age and parity. However, IVF/ICSI twins were
less likely to have birth weight discordance than those spontaneously conceived (unadjusted OR=0.526, 95% CI 0.297-0.932; adjusted
OR=0.486, 95% CI 0.255-0.856). In subgroup analyses, these associations were confirmed in the IVF (adjusted OR=0.496, 95% CI
0.265-0.926), but not in the ICSI group (adjusted OR=0.500, 95% CI 0.139-1.807). Conclusion: IVF/ICSI treatment was not a risk factor for
adverse maternal neonatal outcomes, but the risk for birth weight discordance is lower among IVF/ICSI twins. (IJCEP1308041).

Keywords: In vitro fertilization/intracytoplasmic sperm injection, dichorionic twin pregnancy, maternal outcome, neonatal outcome

Address correspondence to: Dr. Suqing Wang, Department of Nutrition and Food Hygiene, School of Public Health, Wuhan University, 115
Donghu Rd, Wuhan, Hubei, 430071. Tel: (86) 27-68759972; Fax: (86) 27-68758648; E-mail: swang2099@whu.edu.cn