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Int J Clin Exp Pathol 2013;6(11):2350-2356

Original Article
Spermatocytic seminoma: a 21 years’ retrospective study in a tertiary care hospital in
Pakistan

Saroona Haroon, Muhammad Usman Tariq, Saira Fatima, Naila Kayani

Section of Histopathology, Department of Pathology and Microbiology, Aga Khan University, Pakistan

Received August 17, 2013; Accepted September 21, 2013; Epub October 15, 2013; Published November 1, 2013

Abstract: Background: Spermatocytic seminoma is a rare testicular germ cell tumor of old men. Accounting for 1-4% of all seminomas,
spermatocytic seminomas have distinct pathogenesis, histological features, immunohistochemical profile and comparatively benign clinical
behavior which distinguishes them from other germ cell tumors, especially classic seminoma. Aims: The purposes of our study were to
assess the patient demographics, pathological features and to evaluate the utility of CD 117 immunostain along with other
immunohistochemical stains in distinguishing Spermatocytic seminomas from classic seminomas. Material and methods: All spermatocytic
seminomas patients diagnosed during 1992 to 2013 at Section of Histopathology, Department of Pathology and Microbiology, Aga Khan
University hospital were included. Patient characteristics, histological details and follow-up data of few patients were available. CD 117
expression was determined by immunohistochemistry. Results: Total 16 cases of Spermatocytic seminomas were reviewed. Median age was
60 years and average tumor size was 10.4 cms. Microscopically, all of the 16 cases showed presence of edema and absence of lymphocytic
infiltrate and intratubular germ cell neoplasia. Cytoplasmic glycogen was negative in all 13 cases, PLAP immunostain was negative in all 12
cases, while CD 117 was positive in all 8 cases, where applied. Conclusion: CD 117 is of limited utility in differentiating the spermatocytic
seminoma from classic seminoma as it is expressed in significant number of spermatocytic seminomas. However, different histological
features, PAS special stain and PLAP immunostain are significantly helpful in distinguishing these two entities. (IJCEP1308047).

Keywords: Testicular tumour, spermatocytic seminoma, germ cell neoplasm, classic seminoma

Address correspondence to: Dr. Saroona Haroon, Section of Histopathology, Department of Pathology and Microbiology, Aga Khan University,
Pakistan. Tel: 0092-3486-4347; Fax: +92 21 493 4294; E-mail: saroonakm@yahoo.com