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Int J Clin Exp Pathol 2013;6(11):2625-2630

Case Report
Metastasis of lung adenosquamous carcinoma to meningioma: case report with literature
review

Ryan Glass, Supriya R Hukku, Bruce Gershenhorn, Juan Alzate, Bradford Tan

Department of Radiation Biology, Memorial Sloan Kettering Cancer Center, New York, NY; Department of Pathology, Cancer Treatment Centers
of America at Midwestern Regional Medical Center, Zion, IL, USA; Department of Oncology, Cancer Treatment Centers of America, Zion, IL,
USA; Department of Neurosurgery, Cancer Treatment Centers of America, Zion, IL, USA

Received August 21, 2013; Accepted September 20, 2013; Epub October 15, 2013; Published November 1, 2013

Abstract: The occurrence of metastasis of a systemic neoplasm to an intracranial tumor is a rare phenomenon. Meningiomas have been
reported as the most common intracranial tumor to harbor a systemic metastasis, with breast and lung carcinomas being the most common
sites of origination. Here, we report a case of an adenocarcinoma metastasis of an adenosquamous lung carcinoma found within a
meningioma, resulting in the patient’s first clinical manifestations. We also review the literature for other cases of adenocarcinoma metastatic
to a meningioma and suggest mechanisms that make meningiomas likely to harbor systemic metastases including increased vascularity,
slow growth rate, increased hyaline content and expression of cell-cell adhesion molecules. (IJCEP1308057).

Keywords: Tumor-to-tumor, meningioma, adenosquamous carcinoma

Address correspondence to: Dr. Supriya R Hukku, Department of Pathology, Cancer Treatment Centers of America at Midwestern Regional
Medical Center, 2520 Elisha Avenue, Zion, IL 60099, USA. Tel: 847- 872-7590; Fax: 847-746-6781; E-mail: Supriya.Hukku@ctca-hope.com