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Int J Clin Exp Pathol 2013;6(11):2542-2547

Original Article
High frequency of coexpression of maspin with p63 and p53 in squamous cell carcinoma
but not in adenocarcinoma of the lung

Bonnie Choy, Jennifer J Findeis-Hosey, Faqian Li, Loralee A McMahon, Qi Yang, Haodong Xu

Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA

Received August 25, 2013; Accepted September 10, 2013; Epub October 15, 2013; Published November 1, 2013

Abstract: Maspin, a member of the serpin family of protease inhibitors, has been shown to inhibit tumor growth and suppress metastasis in
several malignancies, including lung cancer. Previous studies have reported that p63 and p53 control maspin expression by transactivating the
promoter. The present study analyzed immunohistochemical studies to determine the expression and coexpression patterns of maspin, p63
and p53 in non-small cell lung carcinoma, specifically squamous cell carcinoma and adenocarcinoma. The results showed that 83/86 cases
(96.5%) of squamous cell carcinoma and 82/161 cases (50.9%) of adenocarcinoma included in this study were positive for maspin. There
were 79/86 cases (91.9%) of squamous cell carcinoma and 16/161 cases (9.9%) of adenocarcinoma with positive expression for p63. In
addition, 77/86 cases (89.5%) of squamous cell carcinoma and 99/161 cases (61.5%) of adenocarcinoma were positive for p53. Maspin, p63
and p53 expression were each significantly higher in squamous cell carcinoma than adenocarcinoma. Squamous cell carcinomas more
highly coexpress maspin and p63, as well as maspin and p53, when compared with adenocarcinomas. The high frequency of coexpression of
maspin and p63, as well as maspin and p53, in squamous cell carcinoma, suggests that p63 and p53 may be involved in the pathway to
control maspin expression. Therapeutic targeting on maspin, p63 and p53 molecules might be beneficial in the management of patients with
squamous cell carcinomas of the lung in the future. (IJCEP1308063).

Keywords: Maspin, p63, p53, lung, adenocarcinoma, squamous cell carcinoma

Address correspondence to: Dr. Haodong Xu, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA,
Los Angeles, CA 90095-1732, USA. Tel: 310-206-3285; Fax: 310-267-2058; E-mail: HaodongXu@mednet.ucla.edu