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Int J Clin Exp Pathol 2013;6(11):2548-2553

Original Article
CTLA-4 gene polymorphisms and susceptibility to chronic obstructive pulmonary disease

Lijing Deng, Haixia Zhou, Jing Yang, Jun Xiao, Bo Wang, Lan Wang, Xuemei Ou, Yulin Feng

Department of Intensive Care Unit, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China; Department of Respiratory
Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China. Equal contributors.

Received September 1, 2013; Accepted September 27, 2013; Epub October 15, 2013; Published November 1, 2013

Abstract: Objective: The aim of this study was to investigate whether four single nucleotide polymorphisms (SNPs) in CTLA-4 gene are
associated with chronic obstructive pulmonary disease (COPD) in a Chinese population. Methods: Samples were collected from a Chi­nese
population and analyzed for the association of SNPs in CTLA-4 gene with COPD in a case-control study. Four SNPs (rs231775, rs3087243,
rs231725, rs5742909) in CTLA-4 gene were chosen and genotyped. The results were then analyzed using statistical methods. Results: We
found that none of these four SNPs (rs231775, rs3087243, rs231725, rs5742909) in CTLA-4 gene were associated with the disease.
Conclusion: Our data suggested that there was no significant association between these four SNPs in CTLA-4 gene and COPD susceptibility
in a Chinese population. (IJCEP1309005).

Keywords: CTLA-4, chronic obstructive pulmonary disease, polymorphisms

Address correspondence to: Dr. Yulin Feng, Department of Respiratory Medicine, West China Hospital, Sichuan University, 37#
Guo-Xue-Xiang, Chengdu 610041, Sichuan Province, China. Tel: +86-28-85423660; Fax: +86-28-85423660; E-mail: yulinfeng2@sina.cn; Lijing
Deng, Department of Intensive Care Unit, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China. E-mail:
deng_lijing@163.com