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Int J Clin Exp Pathol 2013;6(12):3019-3022

Case Report
Follicular hybrid cyst: a combination of bullous pilomatricoma and epidermoid cyst

Tutyana Sanusi, Xiaoying Qu, Yanqiu Li, Jing Zhang, Ming Wang, Yun Zhao, Zhen Yang, Xiangjie An, Yue Qian, Chunsen Wang, Hongxiang
Chen, Siyuan Chen, Changzheng Huang

Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China;
Department of Dermatology, The 457th Airforce Hospital, Wuhan 430022, Hubei, China; Department of Dermatology, Zhongshan Hospital,
Wuhan 430030, China; Department of Dermatology, Wuhan General Hospital of Guangzhou Command, Wuhan, 430070, China

Received September 8, 2013; Accepted October 3, 2013; Epub November 15, 2013; Published December 1, 2013

Abstract: The follicular hybrid is composed of more than two components of pilosebaceous unit. There are several studies of hybrid cyst,
combination of trichilemmal and epidermoid cyst was the most frequently reported. In this paper, we reported one case of hybrid cyst
composed of bullous pilomatricoma and epidermoid cyst. A 14-year-old girl was complaint of a solitary flesh-colored to erythematous nodule
with flaccid appearance sized 3.2×1.8 cm in diameter on her right upper back for one year. The histologic findings showed there were edema
and proliferation of capillaries in the superficial dermis, a cyst in the middle to deep dermis. There were laminated keratins in the cystic space.
The cyst wall was composed of two different components, one was composed of epithelial cells containing of granular layer, and another
consisted of basophilic cells, transient cells and shadow cells. The cyst not related with Gardner’s syndrome. Hybrid cyst such as trichilemmal
cyst, epidermoid and pilomatricoma cysts maybe have same clinical features or mimicking each others, but we can distinguish them from
histopathology evaluation. (IJCEP1309026).

Keywords: Hybrid cyst, bullous pilomatricoma, epidermoid cyst

Address correspondence to: Dr. Siyuan Chen or Dr. Changzheng Huang, Department of Dermatology, Union Hospital, Tongji Medical College,
Huazhong University of Science and Technology, Wuhan 430022, China. Tel: +86-27-85726195; E-mail: siyuanc_cn@126.com (SYC);
hcz0501@126.com (CZH)