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Int J Clin Exp Pathol 2013;6(12):2997-3002

Case Report
Endometrial stromal sarcoma arising in vagina

Zhaoxia Liu, Jiao Ding, Xia Li, Kehan Yu

Medical College of Nanchang University, Nanchang, Jiangxi, China; Department of Gynecology, Nanshan Affiliated Hospital of Guangdong
Medical College, Shenzhen, Guangdong, China; Department of Gynecology, Xinyu Maternal and Child Health Care Hospital, Xinyu, Jiangxi,
China; Assisted Reproductive Department of Maternal and Child Health Hospital, Jiujiang, Jiangxi, China; Department of Pathology, First
Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China

Received September 11, 2013; Accepted October 7, 2013; Epub November 15, 2013; Published December 1, 2013

Abstract: Endometrial stromal sarcoma (ESS) arising in the vagina is an extremely rare extrauterine endometrial stroma sarcoma, with only 4
cases reported in the literature up to date. Here we report a case of neoplasm originating from vagina. A 32-year-old woman complained of
intermittent vaginal bleeding especially after intercourse. A mass with a diameter of 1.0 cm was found in the middle and upper segments of the
right posterior vaginal wall. Biopsy showed ESS. Total abdominal hysterectomy, unilateral salpingo-oophorectomy (right) and partial
vaginectomy were performed. No ESS lesion was found in endometrium. The patient received six courses of platinum-containing combination
chemotherapy after surgery and was free of tumor 18 months after the diagnosis of ESS. The diagnosis of ESS relies on pathologic
examination. CD10 is the most useful immunohistochemical marker for the diagnosis of this tumor. The mainstay treatment of ESS is surgery.
Local excision and ovarian retaining may be considered in premenopausal women. (IJCEP1309030).

Keywords: Extrauterine sarcoma, endometrial stromal, vagina, immunohistochemistry

Address correspondence to: Dr. Zhaoxia Liu, Medical college of Nanchang University, 461 Bayi Road, Nanchang, Jiangxi, P. R. China, 330006;
Department of Gynecology, Nanshan Affiliated Hospital of Guangdong Medical College, 89 Taoyuan Road, Nanshan District, Shenzhen,
Guangdong, P. R. China, 518052. Tel: +8618318030772; E-mail: lzxia77@163.com