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Int J Clin Exp Pathol 2013;6(12):2668-2674

Review Article
Regulatory T cells and B cells: implication on autoimmune diseases

Ping Wang, Song Guo Zheng

Division of Liver Transplantation Surgery, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029,
China; Division of Rheumatology, Department of Medicine, Penn State University Hershey College of Medicine, 500 University Dr. H038,
Hershey, PA 17033, USA; Institute of Immunology, Shanghai East Hospital at Tongji University, 150 Jimo Road, Shanghai, 200120

Received September 24, 2013; Accepted October 19, 2013; Epub November 15, 2013; Published December 1, 2013

Abstract: The regulatory T (Treg) cells play an important role in the maintenance of homeostasis and the prevention of autoimmune diseases.
Although most studies are focusing on the role of Treg cells in T cells and T cells-mediated diseases, these cells also directly affect B cells
and other non-T cells. This manuscript updates the role of Treg cells on the B cells and B cell-mediated diseases. In addition, the
mechanisms whereby Treg cells suppress B cell responses have been discussed. (IJCEP1309062).

Keywords: Treg, Foxp3, B cells, antibodies, autoimmune diseases

Address correspondence to: Dr. Ping Wang, Division of Liver Transplantation Surgery, The First Affiliated Hospital of Nanjing Medical
University, 300 Guangzhou Road, Nanjing, 210029, China. E-mail: wuwpzhy@163.com; Dr. Song Guo Zheng, Division of Rheumatology,
Department of Medicine, Penn State University Hershey College of Medicine, 500 University Dr. H038, Hershey, PA 17033, USA. Tel:
717-531-0003; Fax: 717-531-8274; E-mail: szheng1@hmc.psu.edu