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Int J Clin Exp Pathol 2013;6(12):2733-2744
Deoxycytidine kinase promotes the migration and invasion of fibroblast-like
synoviocytes from rheumatoid arthritis patients
Wei Fan, Zhen-Yuan Zhou, Xin-Fang Huang, Chun-De Bao, Fang Du
Department of Rheumatology, Shanghai Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200001, China
Received September 27, 2013; Accepted October 12, 2013; Epub November 15, 2013; Published December 1, 2013
Abstract: Rheumatoid arthritis (RA) is a complex, multi-system disease whose primary site of inflammatory tissue damage is the joint. The
increasing evidences indicate that activated RA fibroblast-like synoviocytes (FLS) play a critical role in the development of pannus by migrating
into cartilage and bone. Furthermore FLS and T cells can activate each other in vitro and in vivo, which is crucial for the progress of RA.
Deoxycytidine kinase (DCK) has been linked to peripheral T cell homeostatic proliferation and survival, which is very important for RA. Yet, the
function of DCK in FLS is still unknown. Here, we present a story that DCK could regulate the migration and invasion of FLS through AKT
pathway in RA patients. Moreover, DCK seems to be the upstream of AKT and FAK, and AKT inhibitor exerted the similar effect on FLS motility.
In summary, our study characterized the new role of DCK in human primary FLS cells, and figured out the possible pathway DCK involved in,
and these findings might propose DCK as a novel target for controlling joint destruction of RA. (IJCEP1309074).
Keywords: Rheumatoid arthritis, deoxycytidine kinase, fibroblast-like synoviocyte, v-akt murine thymoma viral oncogene homolog 1, focal
Address correspondence to: Dr. Fang Du or Dr. Chun-De Bao, Department of Rheumatology, Shanghai Renji Hospital, Shanghai Jiao Tong
University School of Medicine, Shanghai 200001, China. Tel: +86-21-63284622; Fax: +86-21-63113049; E-mail: Dufang_renji@yeah.net;