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Int J Clin Exp Pathol 2013;6(12):3023-3025

Case Report
CD56 positive diffuse large B-cell lymphoma: a case report and literature review

Mi Jin Gu, Jung Ok Ha

Departments of Pathology, Pediatrics, Yeungnam University College of Medicine, Daegu, Korea

Received October 17, 2013; Accepted November 1, 2013; Epub November 15, 2013; Published December 1, 2013

Abstract: CD56 positive B-cell lymphoma is very rare. We experienced a case of CD56 positive diffuse large B-cell lymphoma, occurred in a
young child. A 5-year-old girl complained with snoring and open mouth breathing. No any abnormality in laboratory or physical examination was
present, except enlarged both tonsils. Bilateral tonsillectomy was performed. Cut sections of right tonsil showed a 2 cm size, solid mass. On
microscopically, large monomorphic lymphoid cells were diffusely proliferated and showed positivity for CD20 and CD56 and negative for
Epstein-Barr virus (EBV) polymerase chain reaction (PCR). Monoclonality was observed on immunoglobulin heavy chain gene rearrangement.
This is a unique case with incidentally found and occurred in a young child. (IJCEP1310040).

Keywords: CD56, diffuse large B cell lymphoma, immunohistochemistry

Address correspondence to: Dr. Mi Jin Gu, Department of Pathology, Yeungnam University College of Medicine, 170 Hyeonchung-ro, Nam-gu,
Daegu, Korea. Tel: +82-53-620-3333; Fax: +82-53-622-8432; E-mail: mjgu@yu.ac.kr