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Int J Clin Exp Pathol 1(2):180-184;2008

Case Report
Mucinous Tubular and Spindle Cell Carcinoma of the Kidney with Sarcomatoid
Differentiation

Rochelle A. Simon, MD, P. Anthony di Sant’Agnese, MD, Ganesh S. Palapattu, MD, Eric A. Singer, MD, Grace D. Candelario, MD, Jiaoti Huang,
MD, PhD and Jorge L. Yao, MD

Departments of Pathology, Urology and Medicine University of Rochester Medical Center, Rochester, New York

Received 14 June 2007; accepted 24 June 2007; available online 1 January 2008

surgery were performed, but the patient died from disease progression three weeks postoperatively. MTSC is a recently recognized entity
grade carcinoma, sarcomatoid differentiation may occur and lead to a fatal course, as in all other types of renal cell carcinomas. Adequate that
is considered to be a low-grade carcinoma with a favorable prognosis. Our case demonstrates that although MTSC is usually a low-grade
carcinoma, sarcomatoid differentiation may occur and lead to a fatal course, as in all other types of renal cell carcinomas. Adequate sampling
and the exclusion of sarcomatoid differentiation in the spindle cell component are necessary for proper management and  (IJCEP706001).
prognostication. To our knowledge, this is the first reported case of MTSC with sarcomatoid differentiation and a fatal outcome.
(IJCEP706001).

Key Words: mucinous tubular and spindle cell carcinoma, sarcomatoid differentiation, renal cell carcinoma, renal tumor

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Address all correspondence to: Jorge L. Yao, MD, Genito-Urinary Pathology Section Department of Pathology and Laboratory Medicine
University of Rochester Medical Center - Box 626  601 Elmwood Avenue, Rochester, NY, 14642 E-mail address:
jorge_yao@urmc.rochester.
edu Phone: 585-273-1178 Fax: 585-273-3637