Case Report Nodular Lymphocyte Predominant Hodgkin Lymphoma versus T-cell/histiocyte Rich Large B-cell Lymphoma: The problem in “grey zone” lymphomas
Frank X. Zhao
Department of Pathology, University of Maryland School of Medicine, Baltimore, MD
Received 14 Aug 2007; accepted and available online 1 January 2008
Abstract: Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a rare indolent B-cell lymphoma. However, its morphology can resemble T-cell/histiocyte rich large B-cell lymphoma (T/HRBCL), a subtype of more aggressive diffuse large B-cell lymphoma. More and more studies suggest that these two entities are closely related. In this report, a 59-year-old man with nodal NLPHL and concomitant T/HRBCL in the bone marrow is presented, the current progress in our understanding of these two closely related B-cell lymphomas reviewed and the problems in the diagnosis and differentiation of NLPHL and T/HRBCL discussed. (IJCEP708008).
Address all correspondence to: X. Frank Zhao, MD PhD, Department of Pathology, University of Maryland School of Medicine, 10 S. Pine Street, MSTF 611B, Baltimore, MD 21201, Tel: 410-328-2146, Fax: 410-328-5508, Email: firstname.lastname@example.org