IJCEP Copyright © 2007-All rights reserved.
Int J Clin Exp Pathol 1(1):300-305;2008

Case Report
Nodular Lymphocyte Predominant Hodgkin Lymphoma versus T-cell/histiocyte Rich
Large B-cell Lymphoma: The problem in “grey zone” lymphomas

Frank X. Zhao

Department of Pathology, University of Maryland School of Medicine, Baltimore, MD

Received 14 Aug 2007; accepted and available online 1 January 2008

Abstract: Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a rare indolent B-cell lymphoma. However, its morphology can
resemble T-cell/histiocyte rich large B-cell lymphoma (T/HRBCL), a subtype of more aggressive diffuse large B-cell lymphoma. More and more
studies suggest that these two entities are closely related. In this report, a 59-year-old man with nodal NLPHL and concomitant T/HRBCL in
the bone marrow is presented, the current progress in our understanding of these two closely related B-cell lymphomas reviewed and the
problems in the diagnosis and differentiation of NLPHL and T/HRBCL discussed. (IJCEP708008).

Key words: Nodular lymphocyte-predominant Hodgkin lymphoma, T-cell/histiocyte rich large B-cell lymphoma, “grey zone” lymphoma

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Address all correspondence to: X. Frank Zhao, MD PhD,  Department of Pathology, University of Maryland School of Medicine, 10 S. Pine
Street, MSTF 611B, Baltimore, MD 21201, Tel: 410-328-2146, Fax: 410-328-5508, Email:
xzhao@umm.edu