IJCEP Copyright © 2007-All rights reserved.
Int J Clin Exp Pathol 1(2):105-116;2008

Review Article
Molecular Beacons in Biomedical Detection and Clinical Diagnosis

Youngmi Kim, DoSung Sohn and Weihong Tan

Center for Research at the Bio/nano Interface, Department of Chemistry and UF Genetics Institute, Shands Cancer Center and McKnight Brain
Institute, University of Florida, Gainesville, FL 32611-7200

Received 20 Aug 2007; accepted and available online 1 January 2008

Abstract: Among the diverse nucleic acid probes, molecular beacons (MBs) have shown their excellent potential in a variety of basic
researches and practical applications. Their excellent selectivity, sensitivity, and detection without separation have led them to be particularly
useful in real-time intracellular monitoring of gene expression, development of biosensors, and clinical diagnostics. This paper will focus on
the properties of various MBs and discuss their potential applications. (IJCEP708009)

Key Words: Molecular beacon, DNA, RNA, probe, biosensor, molecular diagnostics

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Address all correspondence to: Dr. Weihong Tan, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA. Tel:
352-846-2410; Fax: 352-846-2410; Email:
tan@chem.ufl.edu