IJCEP Copyright © 2007-All rights reserved.
Int J Clin Exp Pathol 1(5):457-460;2008.

Case Report
Invasive Micropapillary Carcinoma of the Sigmoid Colon: Distinct Morphology and
Aggressive Behavior

Ping Wen, Yiqing Xu, Wendy L. Frankel and Rulong Shen

Departments of Pathology (Drs Shen, Frankel, and Wen) and Internal Medicine (Dr. Xu), The Ohio State University Medical Center, Columbus,
Ohio, USA

Received 6 Sept 2007; accepted and available online 1 January 2008

Abstract: We report a case of invasive micropapillary carcinoma of the sigmoid colon in a 72-year-old female with anemia and abdominal pain.
Grossly, the tumor demonstrated a deeply invasive, ulcerated fungating mass. Microscopically, the carcinoma was predominantly composed of
micropapillae with reversed cell polarity, abundant neutrophils, and surrounded by clear spaces. Multifocal lymphovascular invasion was
present with extensive lymph node metastasis. Immunohistochemically, the carcinoma cells were positive for CDX2, CK20 and monoclonal
carcinoembryonic antigen. They were negative for CK7. The stroma-facing surface of the micropapillae was positive for CD10 and villin,
confirming the inside-out growth pattern characteristic of micropapillary carcinoma. Work-up for distance metastasis was negative. The patient
was alive and well 1.5 years after sigmoidectomy and postoperative chemotherapy. (IJCEP709003).

Key Words: Adenocarcinoma, micropapillary, invasive, metastasis, colon

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Address all correspondence to: Rulong Shen, MD, The Ohio State University Medical Center, S305 Rhodes Hall, 410 W Tenth Avenue,
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