Original Article The Clinical Significance of Massive Intratumoral Lymphocytosis in Squamous Cell Carcinoma of the Anus
Carlos A Rubio, Per J Nilsson, Fredrik Petersson, Ander Höög, Harald Blegen and Runjan Chetty
Departments of Pathology, Karolinska University Hospital, 17176, Stockholm; Surgery, Centre of Gastrointestinal Disease, Ersta Hospital, Stockholm, Sweden and University Health Network, University of Toronto, Toronto, Ontario, Canada
Received 10 Sept 2007 accepted and available online 1 January 2008
Abstract: A recent report indicates that patients with squamouus cell carcinoma of the anus (SCCAC) having intraepithelial lymphocytes, have a poor prognosis. Against that background histological sections from 277 consecutive SCCACs were reviewed searching for cases with massive tumoral-intraepithelial lymphocytosis (TILs; ≥ 50 ITIELs /100 tumor cells). Of the 277 SCCACs, 8 (3 %) had massive TILs. These 8 patients (all females) had both more advanced clinical stage than the remaining 269 control SCCACs patients. Follow-up studies revealed that the 8 patients with SCCACs having massive TILs had a much better 15 years survival rate than control SCCACs patients. It is concluded that despite SCCACs patients with massive TILs had a more advanced clinical stage than SCCACs controls, SCCACs+TILs patients had a longer survival rate (with no deaths after 5 years) than control cases. The search (v.gr. via proteomic methodology) for the lymphocyte-attracting tumor- protein, might bring forward a novel co-adjuvant therapy, capable to increase prolonged survival time in patients having SCCACs without massive TILs. (IJCEP709006).
Address all correspondence to: Carlos A. Rubio, MD, PhD, Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, 17176 Stockholm, Sweden. Fax: 46 8 51774524, Email: Carlos.Rubio@ki.se