IJCEP Copyright © 2007-All rights reserved.
Int J Clin Exp Pathol 1(5):396-402;2008

Review Article
Fibrosing Cholestatic Hepatitis: Clinicopathologic Spectrum, Diagnosis and Pathogenesis

Shu-Yuan Xiao, Liang Lu and Hanlin L. Wang

Departments of Pathology and of Internal Medicine, and Institute for Human Infections and Immunity, University of Texas Medical Branch,
Galveston, Texas; Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California


Received 2 Oct 2007; accepted and available online 1 January 2008

Abstract: Fibrosing cholestatic hepatitis (FCH) is a rapidly progressive, sometimes fatal form of liver injury. Though originally reported in liver
transplant recipients with recurrent hepatitis B, it has now been recognized frequently in chronic hepatitis B or C patients who are under
immunosuppression. The histopathologic hallmarks in the liver include marked hepatocytic injury, severe cholestasis, and periportal and
pericellular fibrosis. The pathogenesis is largely unknown. The aim of this review is to describe the spectrum of clinical conditions in which
FCH occurs, common histopathologic findings, features unique to certain underlying diseases, factors to be considered in differential
diagnosis, and our current understanding of pathogenesis of this disease. (IJCEP710002).

Key Words: Viral hepatitis, hepatitis B virus, hepatitis C virus, liver transplantation, pathogenesis

Full Text  PDF

Address all correspondence to: Shu-Yuan Xiao, M.D., Departments of Pathology and of Internal Medicine, and Institute for Human Infections
and Immunity, Route 0588, University of Texas Medical Branch, 301 University Boulevard, Galveston, Texas; Email:
syxiao@utmb.edu