IJCEP Copyright © 2007-All rights reserved.
Int J Clin Exp Pathol 1(5):403-408;2008

Original Article
Perivascular neuritic dystrophy associated with cerebral amyloid angiopathy in
Alzheimer’s disease

Kenichi Oshima, Hirotake Uchikado, and Dennis W. Dickson

Department of Neuroscience, Mayo Clinic, Jacksonville, Florida

Received 30 Nov 2007; Accepted and available online 1 January 2008

Abstract: Cerebral amyloid angiopathy (CAA) affects both leptomeningeal and parenchymal blood vessels and is common in Alzheimer’s
disease (AD). In some vessels CAA is accompanied by localized neuritic dystrophy around the affected blood vessel. The aim of this study was
to assess the distribution and severity of perivascular neuritic dystrophy in primary visual and visual association cortices.  The severity of
perivascular neuritic dystrophy and Aβ deposition was scored in an association cortex (Brodmann area 18) and a primary cortex (Brodmann
area 17) with double labeling immunohistochemistry for tau and Aβ in 31 cases of AD with severe CAA.  The perivascular tau neuritic dystrophy
score was significantly worse in visual association cortex than in primary visual cortex. On the other hand, there was no difference in the
perivascular Aβ score between the two cortices.  There were positive correlations between the severity of perivascular tau and perivascular Aβ
scores for both primary and association cortices.  The results suggest that the local neuronal environment determines the severity and nature
of the perivascular neuritic pathology more than the severity of the intrinsic vascular disease and suggest a close association between
perivascular amyloid deposits, so-called dyshoric angiopathy, and perivascular neuritic dystrophy. (IJCEP711002).

Key Words: Alzheimer’s disease, amyloid angiopathy, Aβ, tau, neuritic dystrophy, visual cortex

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Address all correspondence to:  Dennis W. Dickson, MD, Neuropathology Laboratory, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL.
32224; Tel: 904-953-7137, Fax: 904-953-7117; Email: