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Int J Clin Exp Pathol 1(5):387-395;2008

Review Article
Hematopoietic Disorders in Down Syndrome

John K. Choi

Division of Hematopathology and Immunohistochemistry, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA

Received December 13, 2007; accepted and available online 1 January 2008

Abstract:Patients with Down syndrome have an increased risk of developing various hematological disorders. In this article, the clinical
characteristics and differential diagnosis of the hematological disorders associated with Down syndrome are reviewed, and the underlying
molecular mechanisms discussed. (IJCEP712003).

Key Words: Down syndrome, transient myeloproliferative disorder, acute leukemia, myelodysplastic syndrome

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Address all correspondence to:  John Kim Choi, M.D., Ph.D., Director of Pediatric Hematopathology and Immunohistochemistry, 802F ARC,
3615 Civic Center Blvd., Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA 19104-4399. Tel: 215-590-7194; Fax:
215-590-0342; Email:
choijo@email.chop.edu or johnkimchoi1@gmail.com