Review Article A Practical and Comprehensive Immunohistochemical Approach to the Diagnosis of Superficial Soft Tissue Tumors
Wael Al-Daraji, Ehab Husain, Bettena G Zelger and Bernhard Zelger
School of Molecular Medical Sciences, Division of Pathology, Queen’s Medical Centre, Nottingham, NG7 2UH, UK
Received 13 March 2008; Accepted in revision 23 April 2008; Available online 10 June 2008
Abstract: Soft tissue tumors include neoplasms of specific and unknown lineages, and, therefore, lineage markers of smooth muscle, skeletal muscle, endothelial, epithelial and Schwann cells have proven useful in everyday practice. However, groups of tumors remain that are defined essentially on grounds of histology; others can be defined by molecular genetic studies. The complex distribution patterns of many antigens and loss of some differentiation antigens in malignant tumors often necessitate the use of panels of antibodies. Optimally such panels should address all significant differential diagnostic alternatives. There is little doubt that numerous new differentiation markers will appear in the future. The evaluation of tumor proliferation, apoptosis, and cell cycle control will give new information related to tumor biology and prognosis. (IJCEP803010).