IJCEP Copyright © 2007-All rights reserved.
Int J Clin Exp Pathol 1(6), 461-474; 2008

Review Article
HOX Proteins and Leukemia

Kajal V. Sitwala, Monisha N. Dandekar and Jay L. Hess

Department of Pathology, The University of Michigan Medical School, Ann Arbor, Michigan, 48109, USA

Received March 24, 2008; accepted and available online March 30, 2008

Abstract: HOX and three amino acid loop extension (TALE) proteins cooperate to induce transformation in mouse leukemia models, and are
dysregulated in a variety of human leukemias.  Despite decades of research, the mechanism of action for HOX proteins in embryogenesis and
hematopoiesis remains unclear.  Recent studies on the roles of Hoxa9 and Meis1 in leukemia has led to a wealth of new data, but their
molecular mechanisms of action and synergy remain obscure.  Advances in genome-wide technologies offer new avenues for understanding
how homeodomain-containing transcription factors exert their programs in normal and neoplastic development. (IJCEP803015).

Key Words: HOX, leukemia

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Address all correspondence to: Jay L. Hess M.D., Ph.D, M5240 Medical Sciences I, 1301 Catherine Street, Ann Arbor, MI 48109-0602, Phone:
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jayhess@umich.edu