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Int J Clin Exp Pathol 2(2):163-168;2009.

Original Article
Pharmacogenetic Contribution of Leptin Gene Polymorphism in Cutaneous T-Cell
Lymphoma

Vladimir Vasku, Anna Vasku and Julie Bienertova Vasku

First Department of Dermatology, St. Ann’s Faculty Hospital and Department of Pathophysiology, Faculty of Medicine, Masaryk University, Brno,
Czech Republic

Received 11 June 2008; Accepted in revision 3 July 2008; Available online 18 July 2008

Abstract: Leptin has recently attracted more attention due to its specific effects in the pathogenesis of malignancies. The aim of this study was
to investigate the possible association between variants of -2548 G/A polymorphism in leptin (LEP) gene and cutaneous T-cell lymphomas
(CTCL), with respect to the treatment responsiveness. A sample of 91 patients with CTCL was compared to 198 control individuals. The CTCL
men with AG and/or GG genotype were more likely to receive the topical steroids treatment (odds ratio 7.88, 95% confidential interval 1.51-
41.04) when compared to AA patients. Our data supports the possible involvement of LEP-2548G/A polymorphism in CTCL treatment
responsiveness and thus might provide important information for individual therapy tailoring.(IJCEP806005 ).

Key Words: Leptin, gene polymorphism, pharmacogenetics, cutaneous T-cell lymphoma

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Address all correspondence to: Professor Anna Vasku, MD., CSc., Department of Pathophysiology, Faculty of Medicine, Masaryk University,
Komenského nám. 2, 66243 Brno, Czech Republic. Tel: +420549498262; Fax: +420549494340; Email:
avasku@med.muni.cz