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Int J Clin Exp Pathol 2(3),304-309;2009.

Case Report
Large Cell Neuroendocrine Carcinoma of the Ovary Associated with Serous Carcinoma
with Mucin Production: A Case Report and Literature Review

Rossitza Anguelova Draganova-Tacheva, Jasvirs S Khurana, Yajue Huang, Enrique Hernandez and Xinmin Zhang

Department of Pathology and Laboratory Medicine, Temple University Hospital, Philadelphia, Pennsylvania, USA; Division of Gynecologic
Oncology, Temple University Hospital, Philadelphia, Pennsylvania, USA;

Received 16 August 2008; Accepted in revision 16 October 2008; Available online 8 November 2008

Abstract: Large cell neuroendocrine carcinoma of ovary (LCNEC) is a rare entity and is frequently associated with ovarian surface epithelial
tumors. However, its association with serous carcinoma with mucin production has not been described.  We report the first case of such in a
68-year old woman. Immunohistochemistry and mucicarmine stain confirmed the diagnosis. Its clinicopathologic association is discussed
and the literature is reviewed. (IJCEP808004).

Key Words: Ovary, neuroendocrine carcinoma, non-small cell type, serous carcinoma, immunohistochemistry

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Address all correspondence to: Xinmin Zhang, MD, Department of Pathology and Laboratory Medicine, Temple University, School of Medicine,
3401 N. Broad Street, Philadelphia, PA 19140, 215-707-8132 (FAX), E-mail:
zhangxx@tuhs.temple.edu