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Int J Clin Exp Pathol 2(3),205-210;2009

Review Article
FoxP3: A Life beyond Regulatory T Cells

Yang Liu, and Pan Zheng

Departments of Surgery, Internal Medicine and Pathology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA

Received 1 October 2008; Accepted and available online 2 October 2008

Abstract: This review analyzes the current dogma that FoxP3 functions exclusively in the regulatory T cells (Treg) and that FoxP3+ Treg is
indispensable for survival of immune competent mice. We outline evidence that FoxP3 is expressed well beyond Treg and that the FoxP3
mutation in thymic stromal cells causes defective thymopoiesis, which in turn leads to increased homeostatic proliferation. We argue that the
lethal autoimmune disease in mice with germline mutation of FoxP3 is due to both lack of Treg and enhanced homeostatic proliferation.
(IJCEP810001).

Key Words: FoxP3, homeostatic proliferation, thymopoiesis, autoimmune diseases

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Address all correspondence to: Dr. Yang Liu, BSRB 2059, University of Michigan, 109 Zina Pitcher Place, Ann Arbor, MI 48109, USA. Tel:
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yangl@umich.edu