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Int J Clin Exp Pathol 2(4),407-410;2009

Case Report
North American Erionite-associated Mesothelioma with Pleural Plaques and Pulmonary
Fibrosis---A Case Report

Corrine R. Kliment, Kristen Clemens and Tim D. Oury

Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; RJ Lee Group, 350 Hochbers Road, Monroeville, PA
15146, USA

Received 9 October 2008; Accepted 28 October 2008; Available online 15 December 2008

Abstract: Erionite, a fibrous zeolite mineral, has been categorized as a class I carcinogenic agent for its causative role in mesothelioma. In
select villages in Turkey, erionite is the cause of more than 50% of mesotheliomas. In contrast, in the United States mesotheliomas are
frequently associated with asbestos exposure. We describe the first reported case of a patient with erionite-associated pleural mesothelioma
with classic pathologic changes typical of asbestos-related pulmonary and pleural pathology. This case report indicates
that in addition to Turkey, erionite-associated disease can occur in North America and that subjects with erionite exposure are not only at risk of
developing mesothelioma, but may develop interstitial fibrosis and additional pulmonary pathology impacting lung function and survival.
(IJCEP810006).

Key Words: Mesothelioma, pulmonary fibrosis, zeolite, erionite, ferruginous bodies.

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Address all correspondence to: Tim D. Oury, MD, PhD, Department of Pathology, University of Pittsburgh, 200 Lothrop St., Biomedical Sciences
Tower, W905, Pittsburgh, PA 15261, Phone: 412-648-9659, Fax: 412-648-9172, Email:
tdoury@pitt.edu