Review Article High-grade Prostatic Intraepithelial Neoplasia of the Prostate: The Precursor Lesion of Prostate Cancer
Debra L Zynger and Ximing Yang
Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA and Department of Pathology, Northwestern University School of Medicine, Chicago, IL
Received 01 December 2008; Accepted and available online 22 December 2008
Abstract: High-grade intraepithelial neoplasia (HGPIN) is a lesion which is widely believed to be a precursor of prostatic adenocarcinoma. Correct morphologic identification of HGPIN and an understanding of how this diagnosis affects clinical management in the research setting are necessary as HGPIN is a premalignant lesion with many genetic alterations similar to prostate cancer, but is not yet invasive cancer. As such it is critical to differentiate between benign entities, HGPIN, and prostatic adenocarcinoma for experimental design and data interpretation. This review discusses HGPIN, clarifies the terminology used in pathology reports, and describes the clinical and research implications of this entity. (IJCEP812001).
Address all correspondence to: Ximing J. Yang, MD, PhD, Department of Pathology, Feinberg 7-334, Northwestern Memorial Hospital, Northwestern University, Feinberg School of Medicine, 251 East Huron Street, Chicago, IL 60611, Tel (312) 926-0931, Fax (312) 926-3127, E-mail: firstname.lastname@example.org