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Int J Clin Exp Pathol 2(4),327-338;2009

Review Article
High-grade Prostatic Intraepithelial Neoplasia of the Prostate: The Precursor Lesion of
Prostate Cancer

Debra L Zynger and Ximing Yang

Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA and Department of Pathology, Northwestern University School
of Medicine, Chicago, IL

Received 01 December 2008; Accepted and available online 22 December 2008

Abstract: High-grade intraepithelial neoplasia (HGPIN) is a lesion which is widely believed to be a precursor of prostatic adenocarcinoma.
Correct morphologic identification of HGPIN and an understanding of how this diagnosis affects clinical management in the research setting
are necessary as HGPIN is a premalignant lesion with many genetic alterations similar to prostate cancer, but is not yet invasive cancer. As
such it is critical to differentiate between benign entities, HGPIN, and prostatic adenocarcinoma for experimental design and data interpretation.
This review discusses HGPIN, clarifies the terminology used in pathology reports, and describes the clinical and research implications of this
entity. (IJCEP812001).

Key Words: High-grade prostatic intraepithelial neoplasia, HGPIN, prostate, needle biopsy

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Address all correspondence to: Ximing J. Yang, MD, PhD, Department of Pathology, Feinberg 7-334, Northwestern Memorial Hospital,
Northwestern University, Feinberg School of Medicine, 251 East Huron Street, Chicago, IL 60611, Tel (312) 926-0931, Fax (312) 926-3127,