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Int J Clin Exp Pathol 2(4),489-493;2009

Original Article
Clinicopathologic Features of Renal Cell Carcinoma in Young Adults: A Comparison
Study with Renal Cell Carcinoma in Older Patients

Jae Hee Suh, Tina Oak, Jae Y. Ro, Luan D. Truong, Alberto G. Ayala and Steven S. Shen

Department of Pathology, Ulsan University Hospital, Ulsan, Korea and Department of Pathology, The Methodist Hospital and Research
Institute, Weill Medical College of Cornell University, Houston, TX 77030

Received 10 December 2008; Accepted 20 January 2009; Available online 30 January 2009

Abstract: To evaluate the clinicopathologic features of renal cell carcinoma in younger adults (≤40 years), we retrospectively reviewed 838
consecutive cases of renal cell carcinoma (RCC) occurred in a single tertiary hospital. Forty-four 44 (5.2%) cases occurred in the young adult
group (24 to 40 years of age). Clinicopathologic features including tumor size, stage, histologic subtype, lymph node and distant metastasis,
and overall survival were compared with that of cases occurred in older age group (>40 years). The tumor size of the young adult group were
smaller (5.3 vs 5.9 cm) and presented at less advanced stages (T3/T4 tumors, 18% vs 31%) than those occurring in the older age group (>40
years of age). The incidences of chromophobe RCC (12% vs. 6%) and of collecting duct carcinoma (5% vs 0.5%) were higher in the young
adult group. The rate of nodal or distant metastasis was lower in young adult group (5% vs. 8.3%). More patients underwent partial
nephrectomy in younger than older age group (30% vs 19%). There was no overall survival difference at 5 years (77% vs 70%), but there was a
trend for a favorable survival in young adults at 10 years (77% vs 52%). In conclusion, RCC are relatively infrequent in patients who are younger
than 40 years. The tumors in this group appear to be smaller and less advanced at presentation. Chromophobe RCC and collecting duct
carcinoma are more frequently seen. More patients undergo partial nephrectomy and overall long term survival appears to be more favorable.
(IJCEP812002).

Key Words: Renal cell carcinoma, young adult, partial nephrectomy, chromophobe RCC, collecting duct carcinoma

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Address all correspondence to: Steven S. Shen, M.D., Ph.D., Department of Pathology, The Methodist Hospital and Research Institute, 6565
Fannin Street, Houston, Texas 77030. Tel: 713-441-6987; Fax: 713-793-1603; Email:
stevenshen@tmhs.org