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Int J Clin Exp Pathol 2010;3(2):217-221

Case Report
Metastatic poorly differentiated monophasic synovial sarcoma to lung with unknown
primary - a molecular genetic analysis

Rong Rong, Erika E. Doxtader, Jamie Tull, Gustavo de la Roza and Shengle Zhang

Department of Pathology, SUNY Upstate Medical University, Syracuse, NY

Received March 23, 2009; accepted September 21, 2009; available online November 25, 2009

Abstract: Poorly differentiated synovial sarcomas are diagnostically challenging soft tissue tumors. They can be indistinguishable from other
“small blue cell tumors” based on morphology and even immunohistochemical studies. Here we report a rare case of poorly differentiated
metastatic synovial sarcoma to lung without known primary, diagnosed with molecular genetic analysis.  The tumor was negative for EMA and
cytokeratin, previously reported as the most sensitive immunostaining markers for synovial sarcomas. SYT-SSX gene fusion, characteristic for
synovial sarcoma, was identified in this case by FISH and RT-PCR assays. (IJCEP903004).

Key words: Synovial sarcoma, lung, metastatic, molecular genetic

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Address all correspondence to:
Shengle Zhang, MD
Department of Pathology
State University of New York Upstate Medical University
750 East Adams Street
Syracuse, NY-13210
Tel: 315-464-7131
E-mail:
zhangs@upstate.edu