Case Report Metastatic poorly differentiated monophasic synovial sarcoma to lung with unknown primary - a molecular genetic analysis
Rong Rong, Erika E. Doxtader, Jamie Tull, Gustavo de la Roza and Shengle Zhang
Department of Pathology, SUNY Upstate Medical University, Syracuse, NY
Received March 23, 2009; accepted September 21, 2009; available online November 25, 2009
Abstract: Poorly differentiated synovial sarcomas are diagnostically challenging soft tissue tumors. They can be indistinguishable from other “small blue cell tumors” based on morphology and even immunohistochemical studies. Here we report a rare case of poorly differentiated metastatic synovial sarcoma to lung without known primary, diagnosed with molecular genetic analysis. The tumor was negative for EMA and cytokeratin, previously reported as the most sensitive immunostaining markers for synovial sarcomas. SYT-SSX gene fusion, characteristic for synovial sarcoma, was identified in this case by FISH and RT-PCR assays. (IJCEP903004).
Address all correspondence to: Shengle Zhang, MD Department of Pathology State University of New York Upstate Medical University 750 East Adams Street Syracuse, NY-13210 Tel: 315-464-7131 E-mail: firstname.lastname@example.org