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Int J Clin Exp Pathol 2010;3(2):203-209

Case Report
Low-grade sarcoma in classical seminoma---the first case reported

Fredrik Petersson, Michal Michal, Petr Grossmann, Marcello Franco, Michal Zámečník, Ondrej Hes

Department of Pathology, National University Health System, Singapore; Sikl's Department of Pathology, Charles University, Medical Faculty
Hospital, Pilsen, Czech Republic; Department of Pathology, Federal University of Sao Paolo, EPM/UNIFESP, Brazil; Biopticka laborator s.r.o.,
Pilsen, Czech Republic

Received July 5, 2009, accepted September 3, 2009, available online November 1, 2009

Abstract: A 30-year-old male with no previous history of neoplastic disease presented with a 5 cm large testicular tumor. Routine
histopathological examination and immunohistochemical investigation showed a classical seminoma with a contiguous 8 mm large nodule.  
The nodule was separated from the tunica albuginea by tubuli seminiferi showing intratesticular germ cell neoplasia. not otherwise specified
(NOS). The nodule was composed of spindle cells with low-grade nuclear atypia, nuclear and cytoplasmic S100 protein immunoreactivity in
15% of the cells and a proliferative activity of up to 20%. No other germ cell tumor components were found. To the best of our knowledge, we
herein present the first tumor of a pure classical seminoma with an associated low-grade sarcomatous component. (IJCEP907001).

Key words: Testis, classical seminoma, sarcoma

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Fredrik Petersson, MD
Department of Pathology,
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