Original Article Androgen deprivation and stem cell markers in prostate cancers
Yao Tang, Anne W Hamburger, Linbo Wang, Mohammad Afnan Khan, Arif Hussain
Department of Medicine; Department of Pathology; Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore Maryland, Veterans Affairs Medical Center, Baltimore, MD
Received October 20, 2009; accepted November 5, 2009; available online November 10, 2009
Abstract: In our previous studies using human LNCaP xenografts and TRAMP (transgenic adenocarcinoma of mouse prostate) mice, androgen deprivation therapy (ADT) resulted in a temporary cessation of prostate cancer (PCa) growth, but then tumors grew faster with more malignant behaviour. To understand whether cancer stem cells might play a role in PCa progression in these animal models, we investigated the expressions of stem cell-related markers in tumors at different time points after ADT. In both animal models, enhanced expressions of stem cell markers were observed in tumors of castrated mice, as compared to non-castrated controls. This increased cell population that expressed stem cell markers is designated as stem-like cells (SLC) in this article. We also observed that the SLC peaked at relatively early time points after ADT, before tumors resumed their growth. These results suggest that the SLC population may play a role in tumor re-growth and disease progression, and that targeting the SLC at their peak-expression time point may prevent tumor recurrence following ADT.(IJCEP910004).
Address all correspondence to: Yao Tang, MD BRB9040 655 West Baltimore Street Greenebaum Cancer Center University of Maryland School of Medicine Baltimore, MD 21201 Tel: 410-328-6870; FAX: 410-328-2822 E-mail: firstname.lastname@example.org