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Int J Clin Exp Pathol 2010;3(2):128-138

Original Article
Androgen deprivation and stem cell markers in prostate cancers

Yao Tang, Anne W Hamburger, Linbo Wang, Mohammad Afnan Khan, Arif Hussain

Department of Medicine; Department of Pathology; Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore Maryland,
Veterans Affairs Medical Center, Baltimore, MD

Received October 20, 2009; accepted November 5, 2009; available online November 10, 2009

Abstract: In our previous studies using human LNCaP xenografts and TRAMP (transgenic adenocarcinoma of mouse prostate) mice,
androgen deprivation therapy (ADT) resulted in a temporary cessation of prostate cancer (PCa) growth, but then tumors grew faster with more
malignant behaviour. To understand whether cancer stem cells might play a role in PCa progression in these animal models, we investigated
the expressions of stem cell-related markers in tumors at different time points after ADT. In both animal models, enhanced expressions of
stem cell markers were observed in tumors of castrated mice, as compared to non-castrated controls. This increased cell population that
expressed stem cell markers is designated as stem-like cells (SLC) in this article. We also observed that the SLC peaked at relatively early
time points after ADT, before tumors resumed their growth. These results suggest that the SLC population may play a role in tumor re-growth
and disease progression, and that targeting the SLC at their peak-expression time point may prevent tumor recurrence following

Key words: Prostate cancer, stem-like cells, androgen deprivation, xenograft tumor, TRAMP mice

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Address all correspondence to:
Yao Tang, MD
655 West Baltimore Street
Greenebaum Cancer Center
University of Maryland School of Medicine
Baltimore, MD 21201
Tel: 410-328-6870; FAX: 410-328-2822