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Int J Clin Exp Pathol 2010;3(3):319-322
Case Report
Sarcomatoid carcinoma of the prostate: a case report
Adamantia Zizi-Sermpetzoglou, Vassiliki Savvaidou, Nikolaos Tepelenis, Nikolaos Galariotis, Michalis Olympitis, Konstantinos Stamatiou
Pathology department, Tzaneion General Hospital of Pireas, Pireas Greece; Urology department Tzaneion General Hospital of Pireas, Pireas
Greece.
Received January 13, 2009; accepted January, 2010; available online January, 2010
Abstract: Sarcomatoid carcinoma of the prostate is a rare variant of prostatic cancer, with less than 100 cases reported in the literature up to
date. Tumors are most commonly composed of an admixture of both malignant glandular and spindle cell elements. The sarcomatoid
component can vary from 5 to 99%. We report a case of a 76-year old Caucasian man who underwent transurethral resection of the prostate for
the treatment of bladder outlet obstruction. Histopathologic examination revealed a tumor with malignant epithelial and sarcomatous elements.
The malignant epithelial component was consisted of poorly differentiated adenocarcinoma (Gleason score 5+4=9/10) and the sarcomatous
component was mainly composed of undifferentiated spindle cells. On immunohistochemistry the latter expressed a positive staining for
vimentin. Several cells were positively stained for cytockeratin AE3 and myoD1 whille all were negatively stainined for actin, desmin and
myogenin. The diagnosis of sarcomatoid carcinoma was finally made. Although sarcomatoid carcinoma of the prostate is a highly aggressive
neoplasm and patients have a poor prognosis, our patient is still alive 1 year after diagnosis. (IJCEP1001005).
Key words: Prostate cancer, sarcomatoid carcinoma, carcinosarcoma, immunohistochemistry, vimentin, cytockeratin AE1/3.
Full text PDF
Address all correspondence to:
Dr. Zizi Sermpetzoglou A.
PO Box 3143 Alikos, Ag Marina
Koropi, 19400, Greece
e-mail:adserbet@yahool.gr
Case Report
Sarcomatoid carcinoma of the prostate: a case report
Adamantia Zizi-Sermpetzoglou, Vassiliki Savvaidou, Nikolaos Tepelenis, Nikolaos Galariotis, Michalis Olympitis, Konstantinos Stamatiou
Pathology department, Tzaneion General Hospital of Pireas, Pireas Greece; Urology department Tzaneion General Hospital of Pireas, Pireas
Greece.
Received January 13, 2009; accepted January, 2010; available online January, 2010
Abstract: Sarcomatoid carcinoma of the prostate is a rare variant of prostatic cancer, with less than 100 cases reported in the literature up to
date. Tumors are most commonly composed of an admixture of both malignant glandular and spindle cell elements. The sarcomatoid
component can vary from 5 to 99%. We report a case of a 76-year old Caucasian man who underwent transurethral resection of the prostate for
the treatment of bladder outlet obstruction. Histopathologic examination revealed a tumor with malignant epithelial and sarcomatous elements.
The malignant epithelial component was consisted of poorly differentiated adenocarcinoma (Gleason score 5+4=9/10) and the sarcomatous
component was mainly composed of undifferentiated spindle cells. On immunohistochemistry the latter expressed a positive staining for
vimentin. Several cells were positively stained for cytockeratin AE3 and myoD1 whille all were negatively stainined for actin, desmin and
myogenin. The diagnosis of sarcomatoid carcinoma was finally made. Although sarcomatoid carcinoma of the prostate is a highly aggressive
neoplasm and patients have a poor prognosis, our patient is still alive 1 year after diagnosis. (IJCEP1001005).
Key words: Prostate cancer, sarcomatoid carcinoma, carcinosarcoma, immunohistochemistry, vimentin, cytockeratin AE1/3.
Full text PDF
Address all correspondence to:
Dr. Zizi Sermpetzoglou A.
PO Box 3143 Alikos, Ag Marina
Koropi, 19400, Greece
e-mail:adserbet@yahool.gr
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