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Int J Clin Exp Pathol 2013;6(2):191-198
Original Article
A clinicopathologic study of esophageal 860 benign and
malignant lesions in 910 cases of consecutive
esophageal biopsies
Tadashi Terada
Department of Pathology, Shizuoka City Shimizu Hospital, Shizuoka, Japan
Received January 10, 2012; Accepted November 24, 2012; Epub January 15, 2013; Published February 1, 2013
Abstract: The author reviewed 910 cases of consecutive esophageal biopsies in the last 15 year in the pathology
laboratory of our hospital. There were 693 normal mucosa and benign lesions (76.2%) and 217 malignant lesions
(23.8%). No significant changes were recognized in the esophagus in 50 biopsies (5.5%). In benign lesions, the
number and frequency (percentages) were as follows: 263 chronic esophagitis (28.9%), 98 heterotopic gastric
mucosa (10.8%), 3 heterotopic colonic mucosa (0.3%), 71 glycogenic acanthosis (7.8%), 68 candidiasis (7.5%), 35
benign ulcer (3.8%), 41 squamous papilloma (4.5%), 4 granular cell tumor (0.4%), 1 tubular adenoma (0.1%), 2
cytomegalovirus esophagitis (0.2%), 3 leiomyoma (0.3%), 17 basal cell hyperplasia (1.9%), and 37 Barrett’s epithelium
(4%). In malignant lesions, the number and frequency (percentages) were as follows: 53 mild dysplasia (5.8%),
29 moderate dysplasia (3.2%), 31 severe dysplasia (3.4%), 13 carcinoma in situ (1.4%), 68 squamous cell carcinoma
(7.5%), 7 primary adenocarcinoma (0.8%), 1 primary signet ring cell carcinoma (0.1%), 4 primary small cell
carcinoma (0.4%), 2 primary amelanotic malignant melanoma (0.2%), 1 primary undifferentiated sarcoma (0.1%), 7
gastric cancer invasion (0.8%), and 1 primary adenoid cystic carcinoma (0.1%). In this article, the clinicopathologic
features of these esophageal lesions were described. (IJCEP1201004).
Keywords: Esophagus, benign lesions, malignant lesions, clinicopathologies, immunohistochemistry
Address all correspondence to:
Dr. Tadashi Terada
Department of Pathology
Shizuoka City Shimizu Hospital
Miyakami 1231 Shimizu-Ku
Shizuoka 424-8636, Japan.
Tel: 81-54-336-1111; Fax: 81-54-336-1315
E-mail: piyo0111jp@yahoo.co.jp
Original Article
A clinicopathologic study of esophageal 860 benign and
malignant lesions in 910 cases of consecutive
esophageal biopsies
Tadashi Terada
Department of Pathology, Shizuoka City Shimizu Hospital, Shizuoka, Japan
Received January 10, 2012; Accepted November 24, 2012; Epub January 15, 2013; Published February 1, 2013
Abstract: The author reviewed 910 cases of consecutive esophageal biopsies in the last 15 year in the pathology
laboratory of our hospital. There were 693 normal mucosa and benign lesions (76.2%) and 217 malignant lesions
(23.8%). No significant changes were recognized in the esophagus in 50 biopsies (5.5%). In benign lesions, the
number and frequency (percentages) were as follows: 263 chronic esophagitis (28.9%), 98 heterotopic gastric
mucosa (10.8%), 3 heterotopic colonic mucosa (0.3%), 71 glycogenic acanthosis (7.8%), 68 candidiasis (7.5%), 35
benign ulcer (3.8%), 41 squamous papilloma (4.5%), 4 granular cell tumor (0.4%), 1 tubular adenoma (0.1%), 2
cytomegalovirus esophagitis (0.2%), 3 leiomyoma (0.3%), 17 basal cell hyperplasia (1.9%), and 37 Barrett’s epithelium
(4%). In malignant lesions, the number and frequency (percentages) were as follows: 53 mild dysplasia (5.8%),
29 moderate dysplasia (3.2%), 31 severe dysplasia (3.4%), 13 carcinoma in situ (1.4%), 68 squamous cell carcinoma
(7.5%), 7 primary adenocarcinoma (0.8%), 1 primary signet ring cell carcinoma (0.1%), 4 primary small cell
carcinoma (0.4%), 2 primary amelanotic malignant melanoma (0.2%), 1 primary undifferentiated sarcoma (0.1%), 7
gastric cancer invasion (0.8%), and 1 primary adenoid cystic carcinoma (0.1%). In this article, the clinicopathologic
features of these esophageal lesions were described. (IJCEP1201004).
Keywords: Esophagus, benign lesions, malignant lesions, clinicopathologies, immunohistochemistry
Address all correspondence to:
Dr. Tadashi Terada
Department of Pathology
Shizuoka City Shimizu Hospital
Miyakami 1231 Shimizu-Ku
Shizuoka 424-8636, Japan.
Tel: 81-54-336-1111; Fax: 81-54-336-1315
E-mail: piyo0111jp@yahoo.co.jp
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