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Int J Clin Exp Pathol 2013;6(2):308-313
Case Report
A rare case of adult hepatoblastoma with
neuroendocrine differentiation misdiagnosed
as neuroendocrine tumor
Qingfu Zhang, Jian Ming, Siyang Zhang, Dawei Guo, Xueshan Qiu
Department of Pathology, the First Affiliated Hospital and College of Basic Medical Sciences, China Medical
University, Shenyang, PR China; Department of Pathology, No. 202 Hospital of People Liberation Army of China,
Shenyang, PR China; Center of Laboratory Technology and Experimental Medicine, China Medical University,
Shenyang, PR China; Department of Surgery, the Fourth Affiliated Hospital of China Medical University,
Shenyang, PR China
Received November 4, 2012; Accepted December 5, 2012; Epub January 15, 2013; Published February 1, 2013
Abstract: Hepatoblastoma is the most common malignant liver tumor between the age of 6 months and 3 years,
but it is extremely rare in adults. Only Forty-five cases of adult hepatoblastoma were reported up to now in the world.
Hepatoblastoma exhibits a wide range of epithelial and mesenchymal lines differentiation, but neuroendocrine
differentiation of this tumor has rare been reported in the literature. Here, we reported a case of primary giant
hepatoblastoma (about 11.4*7.9*15.3cm) with neuroendocrine differentiation of a 32-year-old woman, which was
misdiagnosed as neuroendocrine tumor. (IJCEP1211003).
Keywords: Hepatoblastoma, neuroendocrine tumour (NET), immunohistochemistry, squamous corpuscles
Address all correspondence to:
Dr. Xueshan Qiu
Department of Pathology
The First Affiliated Hospital and College of Basic Medical Sciences
China Medical University, Shenyang, PR China.
E-mail: cmupathology@163.com
Case Report
A rare case of adult hepatoblastoma with
neuroendocrine differentiation misdiagnosed
as neuroendocrine tumor
Qingfu Zhang, Jian Ming, Siyang Zhang, Dawei Guo, Xueshan Qiu
Department of Pathology, the First Affiliated Hospital and College of Basic Medical Sciences, China Medical
University, Shenyang, PR China; Department of Pathology, No. 202 Hospital of People Liberation Army of China,
Shenyang, PR China; Center of Laboratory Technology and Experimental Medicine, China Medical University,
Shenyang, PR China; Department of Surgery, the Fourth Affiliated Hospital of China Medical University,
Shenyang, PR China
Received November 4, 2012; Accepted December 5, 2012; Epub January 15, 2013; Published February 1, 2013
Abstract: Hepatoblastoma is the most common malignant liver tumor between the age of 6 months and 3 years,
but it is extremely rare in adults. Only Forty-five cases of adult hepatoblastoma were reported up to now in the world.
Hepatoblastoma exhibits a wide range of epithelial and mesenchymal lines differentiation, but neuroendocrine
differentiation of this tumor has rare been reported in the literature. Here, we reported a case of primary giant
hepatoblastoma (about 11.4*7.9*15.3cm) with neuroendocrine differentiation of a 32-year-old woman, which was
misdiagnosed as neuroendocrine tumor. (IJCEP1211003).
Keywords: Hepatoblastoma, neuroendocrine tumour (NET), immunohistochemistry, squamous corpuscles
Address all correspondence to:
Dr. Xueshan Qiu
Department of Pathology
The First Affiliated Hospital and College of Basic Medical Sciences
China Medical University, Shenyang, PR China.
E-mail: cmupathology@163.com
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