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Int J Clin Exp Pathol 2013;6(2):155-167
Original Article
Double-hit mantle cell lymphoma with MYC gene
rearrangement or amplification: a report of four
cases and review of the literature
Reza Setoodeh, Stuart Schwartz, Peter Papenhausen, Ling Zhang, Elizabeth M Sagatys, Lynn C Moscinski, Haipeng Shao
Department of Hematopathology, Moffitt Cancer Center and Research Institute, Tampa, FL; Department of
Pathology, University of South Florida, Tampa, FL; Cytogenetics Laboratory, Laboratory Corporation of America,
Research Triangle Park, NC, USA
Received November 23, 2012; Accepted December 12, 2012; Epub January 15, 2013; Published February 1,
2013
Abstract: Mature B-cell lymphomas with both BCL2 and MYC translocations are known as “double hit” lymphomas.
These lymphomas are aggressive and show high proliferation rate due to the growth advantages provided by MYC
and BCL2 translocation and overexpression. Mantle cell lymphoma (MCL) is a neoplasm of mature B-lymphocytes
with characteristic t(11;14) and subsequent Cyclin D1 overexpression. Secondary cytogenetic changes are frequent
in MCL, but MYC translocation has only been rarely reported. In this study, we report four cases of MCL with MYC
translocation or MYC gene amplification detected by conventional cytogenetics, fluorescence in situ hybridization
and whole genome single nucleotide polymorphism (SNP) array, and determined the clinicopathologic features. Our
study provides further evidence supporting the concept of “double hit” MCL with co-involvement of MYC gene rearrangement
and/or amplification and CCND1 gene rearrangement. (IJCP1211021).
Keywords: Mantle cell lymphoma, double hit lymphoma, MYC , 8q24, translocation, amplification
Address all correspondence to:
Dr. Haipeng Shao
Hematopathology and Laboratory Medicine
H Lee Moffitt Cancer Center and Research Institute
12902 Magnolia Drive, Tampa, FL, USA.
Tel: 813-7452672; Fax: 813-7451708
E-mail: Haipeng.Shao@moffitt.org
Original Article
Double-hit mantle cell lymphoma with MYC gene
rearrangement or amplification: a report of four
cases and review of the literature
Reza Setoodeh, Stuart Schwartz, Peter Papenhausen, Ling Zhang, Elizabeth M Sagatys, Lynn C Moscinski, Haipeng Shao
Department of Hematopathology, Moffitt Cancer Center and Research Institute, Tampa, FL; Department of
Pathology, University of South Florida, Tampa, FL; Cytogenetics Laboratory, Laboratory Corporation of America,
Research Triangle Park, NC, USA
Received November 23, 2012; Accepted December 12, 2012; Epub January 15, 2013; Published February 1,
2013
Abstract: Mature B-cell lymphomas with both BCL2 and MYC translocations are known as “double hit” lymphomas.
These lymphomas are aggressive and show high proliferation rate due to the growth advantages provided by MYC
and BCL2 translocation and overexpression. Mantle cell lymphoma (MCL) is a neoplasm of mature B-lymphocytes
with characteristic t(11;14) and subsequent Cyclin D1 overexpression. Secondary cytogenetic changes are frequent
in MCL, but MYC translocation has only been rarely reported. In this study, we report four cases of MCL with MYC
translocation or MYC gene amplification detected by conventional cytogenetics, fluorescence in situ hybridization
and whole genome single nucleotide polymorphism (SNP) array, and determined the clinicopathologic features. Our
study provides further evidence supporting the concept of “double hit” MCL with co-involvement of MYC gene rearrangement
and/or amplification and CCND1 gene rearrangement. (IJCP1211021).
Keywords: Mantle cell lymphoma, double hit lymphoma, MYC , 8q24, translocation, amplification
Address all correspondence to:
Dr. Haipeng Shao
Hematopathology and Laboratory Medicine
H Lee Moffitt Cancer Center and Research Institute
12902 Magnolia Drive, Tampa, FL, USA.
Tel: 813-7452672; Fax: 813-7451708
E-mail: Haipeng.Shao@moffitt.org
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