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Int J Clin Exp Pathol 1(2):105-116;2008
Review Article
Molecular Beacons in Biomedical Detection and Clinical Diagnosis
Youngmi Kim, DoSung Sohn and Weihong Tan
Center for Research at the Bio/nano Interface, Department of Chemistry and UF Genetics Institute, Shands Cancer Center and McKnight Brain
Institute, University of Florida, Gainesville, FL 32611-7200
Received 20 Aug 2007; accepted and available online 1 January 2008
Abstract: Among the diverse nucleic acid probes, molecular beacons (MBs) have shown their excellent potential in a variety of basic
researches and practical applications. Their excellent selectivity, sensitivity, and detection without separation have led them to be particularly
useful in real-time intracellular monitoring of gene expression, development of biosensors, and clinical diagnostics. This paper will focus on
the properties of various MBs and discuss their potential applications. (IJCEP708009)
Key Words: Molecular beacon, DNA, RNA, probe, biosensor, molecular diagnostics
Full Text PDF
Address all correspondence to: Dr. Weihong Tan, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA. Tel:
352-846-2410; Fax: 352-846-2410; Email:tan@chem.ufl.edu
Review Article
Molecular Beacons in Biomedical Detection and Clinical Diagnosis
Youngmi Kim, DoSung Sohn and Weihong Tan
Center for Research at the Bio/nano Interface, Department of Chemistry and UF Genetics Institute, Shands Cancer Center and McKnight Brain
Institute, University of Florida, Gainesville, FL 32611-7200
Received 20 Aug 2007; accepted and available online 1 January 2008
Abstract: Among the diverse nucleic acid probes, molecular beacons (MBs) have shown their excellent potential in a variety of basic
researches and practical applications. Their excellent selectivity, sensitivity, and detection without separation have led them to be particularly
useful in real-time intracellular monitoring of gene expression, development of biosensors, and clinical diagnostics. This paper will focus on
the properties of various MBs and discuss their potential applications. (IJCEP708009)
Key Words: Molecular beacon, DNA, RNA, probe, biosensor, molecular diagnostics
Full Text PDF
Address all correspondence to: Dr. Weihong Tan, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA. Tel:
352-846-2410; Fax: 352-846-2410; Email:tan@chem.ufl.edu
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